Potential Chemoprevention of Paeoniflorin in Colitis-Associated Colorectal Cancer by Network Pharmacology, Molecular Docking, and In Vivo Experiment | |
Si, Xiao-Li2,3; Wang, Yan3,4; Song, Bo-Ni5; Zhang, Yan2; Yang, Qing-Xia2; Li, Zhi5; Luo, Yan-Ping2; Duan, Yong-Qiang1,3; Ma, Xing-Ming2; Zhang, Yan-Ying6 | |
刊名 | CHEMISTRY & BIODIVERSITY |
2022-08-01 | |
卷号 | 19期号:8 |
关键词 | network pharmacology molecular docking paeoniflorin colitis-associated colorectal cancer IL-6 STAT3 |
ISSN号 | 1612-1872 |
DOI | 10.1002/cbdv.202200295 |
英文摘要 | Chronic inflammation plays a positive role in the development and progression of colitis-associated colorectal cancer (CAC). Medicinal plants and their extracts with anti-inflammatory and immunoregulatory properties may be an effective treatment and prevention strategy for CAC. This research aimed to explore the potential chemoprevention of paeoniflorin (PF) for CAC by network pharmacology, molecular docking technology, and in vivo experiments. The results showed that interleukin-6 (IL-6) is a key target of PF against CAC. In the CAC mouse model, PF increased the survival rate of mice and decreased the number and size of colon tumors. Moreover, reduced histological score of colitis and expression of Ki-67 and PCNA were observed in PF-treated mice. In addition, the chemoprevention mechanisms of PF in CAC may be associated with suppression of the IL-6/STAT3 signaling pathway and the IL-17 level. This research provides experimental evidence of potential chemoprevention strategies for CAC treatment. |
WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
语种 | 英语 |
出版者 | WILEY-V C H VERLAG GMBH |
WOS记录号 | WOS:000837201200001 |
内容类型 | 期刊论文 |
源URL | [http://ir.lut.edu.cn/handle/2XXMBERH/159852] |
专题 | 兰州理工大学 |
作者单位 | 1.Gansu Univ Chinese Med, Key Lab Dunhuang Med & Transformat, Minist Educ, 35 East Dingxi Rd, Lanzhou 730030, Peoples R China; 2.Lanzhou Univ, Sch Basic Med Sci, Dept Immunol, 199 West Donggang Rd, Lanzhou 730030, Peoples R China; 3.Gansu Univ Chinese Med, Sch Basic Med Sci, 35 East Dingxi Rd, Lanzhou 730030, Peoples R China; 4.Ningxia Med Univ, Sch Tradit Chinese Med, 1160 Victory St, Yinchuan 750004, Ningxia, Peoples R China; 5.Lanzhou Univ Technol, Sch Life Sci & Engn, 287 LanGongPing Rd, Lanzhou 730050, Peoples R China; 6.Gansu Univ Chinese Med, Sci Res & Expt Ctr, 35 East Dingxi Rd, Lanzhou 730030, Peoples R China |
推荐引用方式 GB/T 7714 | Si, Xiao-Li,Wang, Yan,Song, Bo-Ni,et al. Potential Chemoprevention of Paeoniflorin in Colitis-Associated Colorectal Cancer by Network Pharmacology, Molecular Docking, and In Vivo Experiment[J]. CHEMISTRY & BIODIVERSITY,2022,19(8). |
APA | Si, Xiao-Li.,Wang, Yan.,Song, Bo-Ni.,Zhang, Yan.,Yang, Qing-Xia.,...&Zhang, Yan-Ying.(2022).Potential Chemoprevention of Paeoniflorin in Colitis-Associated Colorectal Cancer by Network Pharmacology, Molecular Docking, and In Vivo Experiment.CHEMISTRY & BIODIVERSITY,19(8). |
MLA | Si, Xiao-Li,et al."Potential Chemoprevention of Paeoniflorin in Colitis-Associated Colorectal Cancer by Network Pharmacology, Molecular Docking, and In Vivo Experiment".CHEMISTRY & BIODIVERSITY 19.8(2022). |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论