Anti-HIV-1 activity and structure-activity-relationship study of a fucosylated glycosaminoglycan from an echinoderm by targeting the conserved CD4 induced epitope

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Anti-HIV-1 activity and structure-activity-relationship study of a fucosylated glycosaminoglycan from an echinoderm by targeting the conserved CD4 induced epitope
	Lian, Wu 1,2; Wu, Mingyi 1; Huang, Ning 3,4; Gao, Na 1; Xiao, Chuang1,2 ; Li, Zi 1; Zhang, Zhigang 1; Zheng, Yongtang 3,4; Peng, Wenlie 2; Zhao, Jinhua1
刊名	BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
	2013-10-01
卷号	1830 期号:10 页码:4681-4691
关键词	Glycosaminoglycan Anti-human immunodeficiency virus activity Envelope glycoprotein 120 Cluster of Differentiation 4 induced epitope Biolayer interferometry Structure-activity relationship
ISSN号	0304-4165
通讯作者	Zheng, YT (reprint author), Chinese Acad Sci, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China.,zhengyt@mail.kiz.ac.cn ; pengwenlie@21cn.com ; zhaojinhua@yahoo.com
英文摘要	Background: Fucosylated glycosaminoglycan (FG) is a novel glycosaminoglycan with a chondroitin sulfate-like backbone and fucose sulfate branches. The aim of this study is to investigate the mechanism and structure-activity relationships (SAR) of FG for combating HIV-1 infection.
学科主题	Biochemistry & Molecular Biology ; Biophysics
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]	Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]	IMMUNODEFICIENCY-VIRUS TYPE-1 ; FREE-RADICAL DEPOLYMERIZATION ; CUCUMBER THELENATA-ANANAS ; CORECEPTOR BINDING-SITE ; ANTI-HIV ACTIVITY ; CHONDROITIN SULFATE ; SEA-CUCUMBER ; ENVELOPE GLYCOPROTEIN ; ANTIRETROVIRAL THERAPY ; DEXTRAN SULFATE
收录类别	SCI
资助信息	Yunnan Provincial Science and Technology Department in China [2010CI116, 2012BC011, 2012FB177]; National Natural Science Foundation of China [81102372]; Outstanding Technical Talent Foundation of the Chinese Academy of Sciences; West Light Foundation of the Chinese Academy of Sciences
语种	英语
WOS记录号	WOS:000323854900031
公开日期	2013-11-12
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/17281]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Sun Yat Sen Univ, Sch Life Sci, Guangzhou 510275, Guangdong, Peoples R China 3.Chinese Acad Sci, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China 4.Chinese Acad Sci, Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Lian, Wu,Wu, Mingyi,Huang, Ning,et al. Anti-HIV-1 activity and structure-activity-relationship study of a fucosylated glycosaminoglycan from an echinoderm by targeting the conserved CD4 induced epitope[J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS,2013,1830(10):4681-4691.
APA	Lian, Wu.,Wu, Mingyi.,Huang, Ning.,Gao, Na.,Xiao, Chuang.,...&Zhao, Jinhua.(2013).Anti-HIV-1 activity and structure-activity-relationship study of a fucosylated glycosaminoglycan from an echinoderm by targeting the conserved CD4 induced epitope.BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS,1830(10),4681-4691.
MLA	Lian, Wu,et al."Anti-HIV-1 activity and structure-activity-relationship study of a fucosylated glycosaminoglycan from an echinoderm by targeting the conserved CD4 induced epitope".BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1830.10(2013):4681-4691.