Exposure to microplastics reduces the bioaccumulation of sulfamethoxazole but enhances its effects on gut microbiota and the antibiotic resistome of mice

doi:10.1016/j.chemosphere.2022.133810

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 中科院海岸带环境过程与生态修复重点实验室

	Exposure to microplastics reduces the bioaccumulation of sulfamethoxazole but enhances its effects on gut microbiota and the antibiotic resistome of mice
	Liu, Jin 2,3; Lv, Min 2; Sun, Anqi 1; Ding, Jing 3; Wang, Yunqing 2; Chang, Xianbo 3; Chen, Lingxin 2
刊名	CHEMOSPHERE
	2022-05-01
卷号	294 页码:7
关键词	Microplastics Antibiotic Bioaccumulation Antibiotic resistance genes Synergistic effect
ISSN号	0045-6535
DOI	10.1016/j.chemosphere.2022.133810
通讯作者	Lv, Min(mlv@yic.ac.cn) ; Chang, Xianbo(cxb780806@126.com) ; Chen, Lingxin(lxchen@yic.ac.cn)
英文摘要	Microplastics (MPs) have aroused a global health concern and their coexistence with antibiotics is inevitable. However, how MPs would affect the bioaccumulation and risks of antibiotics in humans remains poorly understood. Here a mouse model was used, and through dietary exposure, we observed that while the relative distributions of sulfamethoxazole (SMX) in tissues were relatively stable, MPs significantly reduced the bioaccumulation of SMX in mice tissues (liver, lung, spleen, heart and kidney). Notably, while SMX and MPs showed a differential effect, MPs could exacerbate the effects of SMX on gut microbiota and antibiotic resistance gene (ARG) profile, with the relative abundances of sulfonamide resistance genes and multidrug genes being significantly increased. We further identified that shifts in gut microbiota contributed to the changes in ARG profiles in mice. Combined, our results demonstrate that MPs reduced the bioaccumulation of SMX, but they enhanced its effects on gut microbiota and the antibiotic resistome of mice, indicating they might have high risks to humans.
WOS关键词	MYTILUS-EDULIS L. ; RESISTANCE GENES ; POLYETHYLENE ; NANOPLASTICS ; PHARMACEUTICALS ; TOXICITY ; BACTERIA ; SORPTION ; SEA
WOS研究方向	Environmental Sciences & Ecology
语种	英语
WOS记录号	WOS:000758333200006
资助机构	Youth Innovation Promotion Association CAS ; Natural Science Foundation of Shandong Province ; National Natural Science Foundation of China ; Plan Project of Shandong Science and Technology Development ; Taishan Scholar Project Special Funding
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/31513]
专题	烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
通讯作者	Lv, Min; Chang, Xianbo; Chen, Lingxin
作者单位	1.Fujian Normal Univ, Sch Geog Sci, Key Lab Humid Subtrop Ecogeog Proc, Minist Educ, 8 Shangsan Rd, Fuzhou 350007, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, 17 Chunhui Rd, Yantai 264003, Peoples R China 3.Yantai Univ, Sch Environm & Mat Engn, 30 Qingquan Rd, Yantai 264005, Peoples R China
推荐引用方式 GB/T 7714	Liu, Jin,Lv, Min,Sun, Anqi,et al. Exposure to microplastics reduces the bioaccumulation of sulfamethoxazole but enhances its effects on gut microbiota and the antibiotic resistome of mice[J]. CHEMOSPHERE,2022,294:7.
APA	Liu, Jin.,Lv, Min.,Sun, Anqi.,Ding, Jing.,Wang, Yunqing.,...&Chen, Lingxin.(2022).Exposure to microplastics reduces the bioaccumulation of sulfamethoxazole but enhances its effects on gut microbiota and the antibiotic resistome of mice.CHEMOSPHERE,294,7.
MLA	Liu, Jin,et al."Exposure to microplastics reduces the bioaccumulation of sulfamethoxazole but enhances its effects on gut microbiota and the antibiotic resistome of mice".CHEMOSPHERE 294(2022):7.