Chitosan/Gelatin Composite Nonwoven Fabric Scaffold Seeding Minimal Function Unit of Skin for Functional Skin Regeneration

doi:10.1002/mabi.202100419

CORC > 金属研究所 > 中国科学院金属研究所

	Chitosan/Gelatin Composite Nonwoven Fabric Scaffold Seeding Minimal Function Unit of Skin for Functional Skin Regeneration
	Chang, Peng 3; Zhang, Wenchang 4; Wu, Mi 4; Zou, Rufei 4; Song, Xiaoqiang 1; Sun, Qian 2; Gao, Junqing 5; Zhao, Yan 4; Liu, Yunhui 3
刊名	MACROMOLECULAR BIOSCIENCE
	2022-01-12
页码	10
关键词	chitosan gelatin minimal functional unit of skin (MFUS) tissue-engineered skin wound healing
ISSN号	1616-5187
DOI	10.1002/mabi.202100419
通讯作者	Chang, Peng(cp17625@163.com) ; Gao, Junqing(gao-7950@163.com) ; Zhao, Yan(zhaoyan@jihualab.com) ; Liu, Yunhui(liuyh@sj-hospital.org)
英文摘要	The construction of intact functional skin is a challenging field in tissue engineering. Traditional skin tissue engineering, using "seed cells" as a bioactive source for scaffolding materials maybe not efficient enough. Here a new strategy is shown for constructing functional tissue-engineered skin with Minimal Functional Unit of Skin (MFUS) as the source of bioactivity. Chitosan/gelatin non-woven fabric is used as the scaffold. MFUS is derived from autologous skin with full-thickness skin microstructure and complete functional skin unit harvesting. A mathematical model is used to calculate the MFUS Minimal Harvest Diameter and Angle (MHDA). Chitosan/gelatin non-woven fabric (CS+GEL) is porous and absorbable, with an elastic modulus meeting the requirement of skin engineering. It supports layered and 3D growth of MFUS. The degradation rate of chitosan, including filament diameter and density is evaluated in vivo. MFUS-engineered skin could reduce the density of local nerve fibers in the early stage, potentially reducing pain during wound healing, as well as could limit excessive fibroblast cell migration in the later stage, potentially reducing scar formation. This study proposes a new strategy for the clinical treatment of large full-thickness skin defects by constructing intact functional at minimal cost.
资助项目	Shenyang Science and Technology Bureau[19-109-4-02] ; Shenyang Science and Technology Bureau[21-172-9-15] ; Guangdong Climbing Peaks Program for High-level Hospital Development[202000240] ; Science & Technology Department of Liaoning Province[2021-KF-22-16] ; State Key Laboratory of Robotics, China[2021-KF-22-16] ; Shengjing Hospital 345 Talent Project
WOS研究方向	Biochemistry & Molecular Biology ; Materials Science ; Polymer Science
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000741940000001
资助机构	Shenyang Science and Technology Bureau ; Guangdong Climbing Peaks Program for High-level Hospital Development ; Science & Technology Department of Liaoning Province ; State Key Laboratory of Robotics, China ; Shengjing Hospital 345 Talent Project
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/173733]
专题	金属研究所_中国科学院金属研究所
通讯作者	Chang, Peng; Gao, Junqing; Zhao, Yan; Liu, Yunhui
作者单位	1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 2.Gen Hosp Northern Ctr Command, Expt Anim Ctr, Shenyang 110084, Peoples R China 3.China Med Univ, Shengjing Hosp, Dept Plast & Reconstruct & Neurosurg Surg, Shenyang 110004, Peoples R China 4.Jihua Lab, Foshan 528000, Peoples R China 5.Foshan Hosp Tradit Chinese Med, Foshan 528000, Peoples R China
推荐引用方式 GB/T 7714	Chang, Peng,Zhang, Wenchang,Wu, Mi,et al. Chitosan/Gelatin Composite Nonwoven Fabric Scaffold Seeding Minimal Function Unit of Skin for Functional Skin Regeneration[J]. MACROMOLECULAR BIOSCIENCE,2022:10.
APA	Chang, Peng.,Zhang, Wenchang.,Wu, Mi.,Zou, Rufei.,Song, Xiaoqiang.,...&Liu, Yunhui.(2022).Chitosan/Gelatin Composite Nonwoven Fabric Scaffold Seeding Minimal Function Unit of Skin for Functional Skin Regeneration.MACROMOLECULAR BIOSCIENCE,10.
MLA	Chang, Peng,et al."Chitosan/Gelatin Composite Nonwoven Fabric Scaffold Seeding Minimal Function Unit of Skin for Functional Skin Regeneration".MACROMOLECULAR BIOSCIENCE (2022):10.