Anti-infection mechanism of a novel dental implant made of titanium-copper (TiCu) alloy and its mechanism associated with oral microbiology

doi:10.1016/j.bioactmat.2021.05.053

CORC > 金属研究所 > 中国科学院金属研究所

	Anti-infection mechanism of a novel dental implant made of titanium-copper (TiCu) alloy and its mechanism associated with oral microbiology
	Liu, Hui 4,5; Tang, Yulong 1; Zhang, Shuyuan 5; Liu, Huan 4,5; Wang, Zijian 1; Li, Yue 1; Wang, Xinluan 2,3,6; Ren, Ling 5; Yang, Ke 5; Qin, Ling 2,3,6
刊名	BIOACTIVE MATERIALS
	2022-02-01
卷号	8 页码:381-395
关键词	Titanium-copper alloy implants Anti-infection Oral microbiology Biosafety
DOI	10.1016/j.bioactmat.2021.05.053
通讯作者	Ren, Ling(lren@imr.ac.cn) ; Yang, Ke(Kyang@imr.ac.cn) ; Qin, Ling(lingqin@cuhk.edu.hk)
英文摘要	This work was focused on study of anti-infection ability and its underlying mechanism of a novel dental implant made of titanium-copper (TiCu) alloy. In general, most studies on antibacterial implants have used a single pathogen to test their anti-infection ability using infectious animal models. However, dental implant-associated infections are polymicrobial diseases. We innovatively combine the classic ligature model in dogs with sucrose-rich diets to induce oral infections via the canine native oral bacteria. The anti-infection ability, biocompatibility and underlying mechanism of TiCu implant were systematically investigated in comparison with pure Ti implant via general inspection, hematology, imageology (micro-CT), microbiology (16S rDNA and metagenome), histology, and Cu ion detections. Compared with Ti implant, TiCu implant demonstrated remarkable anti-infection potentials with excellent biocompatibility. Additionally, the underlying anti-infection mechanism of TiCu implant was considered to involve maintaining the oral microbiota homeostasis. It was found that the carbohydrates in the plaques formed on the surface of TiCu implant were metabolized through the tricarboxylic acid cycle (TCA) cycles, which prevented the formation of an acidic microenvironment and inhibited the accumulation of acidogens and pathogens, thereby maintaining the microflora balance between aerobic and anaerobic bacteria.
资助项目	Bureau of International Cooperation, Chinese Academy of Sciences[174321KYSB20180006] ; National Key Research and Development Program of China[2018YFC1106600] ; National Key Research and Development Program of China[2016YFC1100600] ; Natural Science Foundation of China[51631009] ; Natural Science Foundation of China[31870954] ; Liaoning Revitalization Talents Program[XLYC1807069]
WOS研究方向	Engineering ; Materials Science
语种	英语
出版者	KEAI PUBLISHING LTD
WOS记录号	WOS:000751867500027
资助机构	Bureau of International Cooperation, Chinese Academy of Sciences ; National Key Research and Development Program of China ; Natural Science Foundation of China ; Liaoning Revitalization Talents Program
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/173428]
专题	金属研究所_中国科学院金属研究所
通讯作者	Ren, Ling; Yang, Ke; Qin, Ling
作者单位	1.Gen Hosp Northern Mil Area, Dept Stomatol, 83 Wenhua Rd, Shenyang 110016, Peoples R China 2.Chinese Univ Hong Kong, Innovat Orthopaed Biomat & Drug Translat Res Lab, Li Ka Shing Inst Hlth, Hong Kong, Peoples R China 3.Chinese Univ Hong Kong, Musculoskeletal Res Lab, Dept Orthopaed & Traumatol, Hong Kong, Peoples R China 4.Univ Sci & Technol China, Sch Mat Sci & Engn, 96 Jinzhai Rd, Hefei 230026, Peoples R China 5.Chinese Acad Sci, Shi Changxu Innovat Ctr Adv Mat, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China 6.Chinese Acad Sci, Translat Med R&D Ctr, Inst Biomed & Hlth Engn, Shenzhen Inst Adv Technol, Shenzhen 518057, Peoples R China
推荐引用方式 GB/T 7714	Liu, Hui,Tang, Yulong,Zhang, Shuyuan,et al. Anti-infection mechanism of a novel dental implant made of titanium-copper (TiCu) alloy and its mechanism associated with oral microbiology[J]. BIOACTIVE MATERIALS,2022,8:381-395.
APA	Liu, Hui.,Tang, Yulong.,Zhang, Shuyuan.,Liu, Huan.,Wang, Zijian.,...&Qin, Ling.(2022).Anti-infection mechanism of a novel dental implant made of titanium-copper (TiCu) alloy and its mechanism associated with oral microbiology.BIOACTIVE MATERIALS,8,381-395.
MLA	Liu, Hui,et al."Anti-infection mechanism of a novel dental implant made of titanium-copper (TiCu) alloy and its mechanism associated with oral microbiology".BIOACTIVE MATERIALS 8(2022):381-395.