A new two-dimensional chromatographic method for separation of saponins from steamed Panax notoginseng

doi:10.1016/j.jpba.2016.04.019

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	A new two-dimensional chromatographic method for separation of saponins from steamed Panax notoginseng
	Lelu, Jimmy K.; Liu, Qi ; Alolga, Raphael N.; Fan, Yong ; Xiao, Wei-Lie ; Qi, Lian-Wen ; Li, Ping 2
刊名	JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
	2016
卷号	125
关键词	Panax notoginseng Saponins Sepbox Rare ginsenosides
ISSN号	0731-7085
DOI	10.1016/j.jpba.2016.04.019
文献子类	Article
英文摘要	The root and rhizome of Panax notoginseng (PNG) are used as folk medicine. Recent studies have reported PNG to possess immunomodulatory, cardioprotective, hepatoprotective, anti-diabetic and anticancer activities among a host of other pharmacological effects. The main active constituents responsible for these pharmacological effects are saponins. It has also been proven that the chemical constituents of steamed PNG differs from the raw form. Traditional methods of separating individual components in crude extracts are usually tedious, almost irreproducible and time-consuming. In this study, an automated multi-step preparative separation system, known as Sepbox afforded a quick, reproducible and fast separation of saponins from PNG. With Sepbox, a total of 11 saponins of high purity were obtained in a short period of time. The separated compounds were identified as notoginsenosides R1, T5, ginsenosides Rb1, Rg1, Rg2, Rh1, Rh4, Rd, 20 (S) -Rg3 and a mixture of ginsenosides Rk1 and Rg5. (C) 2016 Elsevier B.V. All rights reserved.
学科主题	Chemistry, Analytical ; Pharmacology & Pharmacy
电子版国际标准刊号	1873-264X
出版地	AMSTERDAM
WOS研究方向	Science Citation Index Expanded (SCI-EXPANDED)
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000376474400042
内容类型	期刊论文
源URL	[http://ir.ibcas.ac.cn/handle/2S10CLM1/24726]
专题	中科院植物分子生理学重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, Beijing, Peoples R China 2.Qi, Lian-Wen 3.Fan, Yong 4.Alolga, Raphael N. 5.Liu, Qi 6.[Lelu, Jimmy K. 7.China Pharmaceut Univ, State Key Lab Nat Med, 24 Tongjia Lane, Nanjing 210009, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Lelu, Jimmy K.,Liu, Qi,Alolga, Raphael N.,et al. A new two-dimensional chromatographic method for separation of saponins from steamed Panax notoginseng[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2016,125.
APA	Lelu, Jimmy K..,Liu, Qi.,Alolga, Raphael N..,Fan, Yong.,Xiao, Wei-Lie.,...&Li, Ping.(2016).A new two-dimensional chromatographic method for separation of saponins from steamed Panax notoginseng.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,125.
MLA	Lelu, Jimmy K.,et al."A new two-dimensional chromatographic method for separation of saponins from steamed Panax notoginseng".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 125(2016).