Mapping blood traits to structural organization of the brain in rhesus monkeys

doi:10.1093/cercor/bhac065

	Mapping blood traits to structural organization of the brain in rhesus monkeys
	Cui, Yue 1,2,3,8; Huang, Haibin 1,2,3,8; Gao, Jinquan 4,5; Jiang, Tianzi 1,2,3,6,8; Zhang, Chen 7; Yu, Shan 1,2,3,8
刊名	CEREBRAL CORTEX
	2022-03-07
页码	11
关键词	gray matter hematology rhesus monkey serum biochemistry white matter
ISSN号	1047-3211
DOI	10.1093/cercor/bhac065
通讯作者	Zhang, Chen() ; Yu, Shan(czhang@ccmu.edu.can)
英文摘要	Hematological and biochemical blood traits have been linked to brain structural characteristics in humans. However, the relationship between these two domains has not been systematically explored in nonhuman primates, which are crucial animal models for understanding the mechanisms of brain function and developing therapeutics for various disorders. Here we investigated the associations between hematological/biochemical parameters and the brain's gray matter volume and white matter integrity derived from T1-weighted and diffusion magnetic resonance imaging in 36 healthy macaques. We found that intersubject variations in basophil count and hemoglobin levels correlated with gray matter volumes in the anterior cingulum, prefrontal cortex, and putamen. Through interactions between these key elements, the blood parameters' covariation network was linked with that of the brain structures, forming overarching networks connecting blood traits with structural brain features. These networks exhibited hierarchical small-world architecture, indicating highly effective interactions between their constituent elements. In addition, different subnetworks of the brain areas or fiber tracts tended to correlate with unique groups of blood indices, revealing previously unknown brain structural organization. These results provide a quantitative characterization of the interactions between blood parameters and brain structures in macaques and may increase the understanding of the body-brain relationship and the pathogenesis of relevant disorders.
WOS关键词	ALZHEIMERS-DISEASE ; MATTER ; CORTEX ; AGE ; CHOLESTEROL ; COGNITION ; INSIGHTS ; PUTAMEN ; RISK ; SEX
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	OXFORD UNIV PRESS INC
WOS记录号	WOS:000767425900001
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/48060]
专题	自动化研究所_脑网络组研究中心
通讯作者	Zhang, Chen; Yu, Shan
作者单位	1.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing 100190, Peoples R China 2.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Automat, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing 100049, Peoples R China 4.Life Biosci Co Ltd, Model R&D Ctr, Beijing 100176, Peoples R China 5.SAFE Pharmaceut Technol Co Ltd, Technol Management Ctr, Beijing 100176, Peoples R China 6.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 610054, Peoples R China 7.Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Sch Basic Med Sci, Dept Neurobiol,Beijing Key Lab Neural Regenerat &, Beijing 100069, Peoples R China 8.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Cui, Yue,Huang, Haibin,Gao, Jinquan,et al. Mapping blood traits to structural organization of the brain in rhesus monkeys[J]. CEREBRAL CORTEX,2022:11.
APA	Cui, Yue,Huang, Haibin,Gao, Jinquan,Jiang, Tianzi,Zhang, Chen,&Yu, Shan.(2022).Mapping blood traits to structural organization of the brain in rhesus monkeys.CEREBRAL CORTEX,11.
MLA	Cui, Yue,et al."Mapping blood traits to structural organization of the brain in rhesus monkeys".CEREBRAL CORTEX (2022):11.