Diffusion tensor imaging of the hippocampus reflects the severity of hippocampal injury induced by global cerebral ischemia/reperfusion injury

doi:10.4103/1673-5374.322468

	Diffusion tensor imaging of the hippocampus reflects the severity of hippocampal injury induced by global cerebral ischemia/reperfusion injury
	Wang, Wen-Zhu 2,3; Liu, Xu 4; Yang, Zheng-Yi 1; Wang, Yi-Zheng 2; Lu, Hai-Tao 2
刊名	NEURAL REGENERATION RESEARCH
	2022-04-01
卷号	17 期号:4 页码:838-844
关键词	brain-derived neurotrophic factor diffusion tensor imaging fractional anisotropy value global cerebral ischemia/reperfusion injury hippocampus TrkB
ISSN号	1673-5374
DOI	10.4103/1673-5374.322468
通讯作者	Lu, Hai-Tao(13051760807@163.com)
英文摘要	At present, predicting the severity of brain injury caused by global cerebral ischemia/reperfusion injury (GCI/RI) is a clinical problem. After such an injury, clinical indicators that can directly reflect neurological dysfunction are lacking. The change in hippocampal microstructure is the key to memory formation and consolidation. Diffusion tensor imaging is a highly sensitive tool for visualizing injury to hippocampal microstructure. Although hippocampal microstructure, brain-derived neurotrophic factor (BDNF), and tropomyosin-related kinase B (TrkB) levels are closely related to nerve injury and the repair process after GCI/RI, whether these indicators can reflect the severity of such hippocampal injury remains unknown. To address this issue, we established rat models of GCI/RI using the four-vessel occlusion method. Diffusion tensor imaging parameters, BDNF, and TrkB levels were correlated with modified neurological severity scores. The results revealed that after GCI/RI, while neurological function was not related to BDNF and TrkB levels, it was related to hippocampal fractional anisotropy. These findings suggest that hippocampal fractional anisotropy can reflect the severity of hippocampal injury after global GCI/RI. The study was approved by the Institutional Animal Care and Use Committee of Capital Medical University, China (approval No. AEEI-2015-139) on November 9, 2015.
资助项目	Fundamental Research Funds for Central Public Welfare Research Institute of China[2015CZ-36] ; Fundamental Research Funds for Central Public Welfare Research Institute of China[2019CZ-7]
WOS关键词	NEUROTROPHIC FACTOR BDNF ; REPERFUSION ; DEPRESSION ; MEMORY ; VOLUME
WOS研究方向	Cell Biology ; Neurosciences & Neurology
语种	英语
出版者	WOLTERS KLUWER MEDKNOW PUBLICATIONS
WOS记录号	WOS:000754512500031
资助机构	Fundamental Research Funds for Central Public Welfare Research Institute of China
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/48041]
专题	自动化研究所_脑网络组研究中心
通讯作者	Lu, Hai-Tao
作者单位	1.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing, Peoples R China 2.Capital Med Univ, Beijing Boai Hosp, China Rehabil Res Ctr, Sch Rehabil Med, Beijing, Peoples R China 3.Beijing Key Lab Neural Injury & Rehabil, Beijing, Peoples R China 4.Capital Med Univ, Beijing Friendship Hosp, Dept Rehabil Med, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Wang, Wen-Zhu,Liu, Xu,Yang, Zheng-Yi,et al. Diffusion tensor imaging of the hippocampus reflects the severity of hippocampal injury induced by global cerebral ischemia/reperfusion injury[J]. NEURAL REGENERATION RESEARCH,2022,17(4):838-844.
APA	Wang, Wen-Zhu,Liu, Xu,Yang, Zheng-Yi,Wang, Yi-Zheng,&Lu, Hai-Tao.(2022).Diffusion tensor imaging of the hippocampus reflects the severity of hippocampal injury induced by global cerebral ischemia/reperfusion injury.NEURAL REGENERATION RESEARCH,17(4),838-844.
MLA	Wang, Wen-Zhu,et al."Diffusion tensor imaging of the hippocampus reflects the severity of hippocampal injury induced by global cerebral ischemia/reperfusion injury".NEURAL REGENERATION RESEARCH 17.4(2022):838-844.