A novel machine learning-based radiomic model for diagnosing high bleeding risk esophageal varices in cirrhotic patients | |
Yan, Yijie5; Li, Yue4,5; Fan, Chunlei5; Zhang, Yuening5; Zhang, Shibin5; Wang, Zhi3; Huang, Tehui3; Ding, Zhenjia2; Hu, Keqin1; Li, Lei5 | |
刊名 | HEPATOLOGY INTERNATIONAL |
2022-04-01 | |
卷号 | 16期号:2页码:423-432 |
关键词 | Machine learning Radiomic model Esophageal varices Cirrhotic portal hypertension Computed tomography Endoscopy |
ISSN号 | 1936-0533 |
DOI | 10.1007/s12072-021-10292-6 |
通讯作者 | Li, Lei(13699119545@163.com) ; Ding, Huiguo(dinghuiguo@ccmu.edu.cn) |
英文摘要 | Background and aim To develop and validate a novel machine learning-based radiomic model (RM) for diagnosing high bleeding risk esophageal varices (HREV) in patients with cirrhosis. Methods A total of 796 qualified participants were enrolled. In training cohort, 218 cirrhotic patients with mild esophageal varices (EV) and 240 with HREV RM were included to training and internal validation groups. Additionally, 159 and 340 cirrhotic patients with mild EV and HREV RM, respectively, were used for external validation. Interesting regions of liver, spleen, and esophagus were labeled on the portal venous-phase enhanced CT images. RM was assessed by area under the receiver operating characteristic curves (AUROC), sensitivity, specificity, calibration and decision curve analysis (DCA). Results The AUROCs for mild EV RM in training and internal validation were 0.943 and 0.732, sensitivity and specificity were 0.863, 0.773 and 0.763, 0.763, respectively. The AUROC, sensitivity, and specificity were 0.654, 0.773 and 0.632, respectively, in external validation. Interestingly, the AUROCs for HREV RM in training and internal validation were 0.983 and 0.834, sensitivity and specificity were 0.948, 0.916 and 0.977, 0.969, respectively. The related AUROC, sensitivity and specificity were 0.736, 0.690 and 0.762 in external validation. Calibration and DCA indicated RM had good performance. Compared with Baveno VI and its expanded criteria, HREV RM had a higher accuracy and net reclassification improvements that were as high as 49.0% and 32.8%. Conclusion The present study developed a novel non-invasive RM for diagnosing HREV in cirrhotic patients with high accuracy. However, this RM still needs to be validated by a large multi-center cohort. |
资助项目 | State Key Projects Specialized on Infectious Diseases[2017ZX10203202-004] ; Digestive Medical Coordinated Development Center of Beijing Hospitals Authority[XXZ0801] ; Sino-German Cooperation Group[GZ1517] |
WOS关键词 | BAVENO VI CRITERIA ; MANAGEMENT |
WOS研究方向 | Gastroenterology & Hepatology |
语种 | 英语 |
出版者 | SPRINGER |
WOS记录号 | WOS:000777385800001 |
资助机构 | State Key Projects Specialized on Infectious Diseases ; Digestive Medical Coordinated Development Center of Beijing Hospitals Authority ; Sino-German Cooperation Group |
内容类型 | 期刊论文 |
源URL | [http://ir.ia.ac.cn/handle/173211/48213] |
专题 | 数字内容技术与服务研究中心_远程智能医疗 |
通讯作者 | Li, Lei; Ding, Huiguo |
作者单位 | 1.Univ Calif Irvine, Div Gastroenterol & Hepatol, Sch Med, Orange, CA 92668 USA 2.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 3.Blot Info & Tech Beijing Co Ltd, Beijing 101200, Peoples R China 4.Harbin Med Univ, Dept Gastroenterol, Affiliated Hosp 4, Harbin 150001, Heilongjiang, Peoples R China 5.Capital Med Univ, Dept Gastroenterol & Hepatol, Beijing Youan Hosp, Beijing 100069, Peoples R China |
推荐引用方式 GB/T 7714 | Yan, Yijie,Li, Yue,Fan, Chunlei,et al. A novel machine learning-based radiomic model for diagnosing high bleeding risk esophageal varices in cirrhotic patients[J]. HEPATOLOGY INTERNATIONAL,2022,16(2):423-432. |
APA | Yan, Yijie.,Li, Yue.,Fan, Chunlei.,Zhang, Yuening.,Zhang, Shibin.,...&Ding, Huiguo.(2022).A novel machine learning-based radiomic model for diagnosing high bleeding risk esophageal varices in cirrhotic patients.HEPATOLOGY INTERNATIONAL,16(2),423-432. |
MLA | Yan, Yijie,et al."A novel machine learning-based radiomic model for diagnosing high bleeding risk esophageal varices in cirrhotic patients".HEPATOLOGY INTERNATIONAL 16.2(2022):423-432. |
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