Cold Plasma Irradiation Regulates Inflammation and Oxidative Stress in Human Bronchial Epithelial Cells and Human Non-Small Cell Lung Carcinoma

doi:10.1667/RADE-20-00178.1

	Cold Plasma Irradiation Regulates Inflammation and Oxidative Stress in Human Bronchial Epithelial Cells and Human Non-Small Cell Lung Carcinoma
	Sun, Tao 1,2,3; Yu, Shujun 4; Song, Xuegang 2; Zhang, Jin 5; Bao, Qin 2; Mei, Qiong 2; Shen, Qiying 6; Wang, Dong 2; Ni, Guohua 1,3
刊名	RADIATION RESEARCH
	2022-02-01
卷号	197
ISSN号	0033-7587
DOI	10.1667/RADE-20-00178.1
通讯作者	Shen, Qiying(shenqiying-yy@163.com) ; Wang, Dong(wdwade@mail.ustc.edu.cn) ; Ni, Guohua(ghni@ipp.ac.cn)
英文摘要	Atmospheric pressure cold plasma has shown multiple biological effects of anti-bacteria and anti-cancer. In this study, the effect of atmospheric pressure cold plasma on respiratory inflammation and oxidant stress is explored. Tunicamycin was used to stimulate human bronchial epithelial cells (HBECs) and A549 cells for inflammatory response and oxidative stress, followed by atmospheric pressure cold plasma treatment. For HBECs and A549 cells, atmospheric pressure cold plasma was able to alleviate tunicamycin-induced cell proliferation inhibition, inflammation and oxidant stress, and enhance nuclear factor-erythroid-2-related factor 2 (NRF2) pathway activation. Moreover, NRF2/ARE (anti-oxidant response elements) pathway was involved in the regulation of atmospheric pressure cold plasma on tunicamycin-induced oxidative stress. These results suggest the positive effect of atmospheric pressure cold plasma on inflammation and oxidant stress of respiratory system, indicating the therapeutic potential of atmospheric pressure cold plasma for respiratory diseases. (C) 2022 by Radiation Research Society
资助项目	National Key R&D Program of China[2019YFC0119000] ; National Natural Science Foundation of China[31800702] ; National Natural Science Foundation of China[11875295] ; National Natural Science Foundation of China[11535003] ; National Natural Science Foundation of China[81902003] ; Anhui Medical University[XJ201603] ; Anhui Medical University[2017xkj003]
WOS关键词	SYNCYTIAL VIRUS-INFECTION ; HEME OXYGENASE-1 ; KAPPA-B ; EXPRESSION ; ANTIOXIDANT ; INJURY ; RATS
WOS研究方向	Life Sciences & Biomedicine - Other Topics ; Biophysics ; Radiology, Nuclear Medicine & Medical Imaging
语种	英语
出版者	RADIATION RESEARCH SOC
WOS记录号	WOS:000774050400007
资助机构	National Key R&D Program of China ; National Natural Science Foundation of China ; Anhui Medical University
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/128253]
专题	中国科学院合肥物质科学研究院
通讯作者	Shen, Qiying; Wang, Dong; Ni, Guohua
作者单位	1.Chinese Acad Sci, Inst Plasma Phys, Hefei 230031, Anhui, Peoples R China 2.Anhui Med Univ, Sch Basic Med Sci, Hefei 230032, Anhui, Peoples R China 3.Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Anhui, Peoples R China 4.Anhui Med Univ, Dept Obstet & Gynecol, Affiliated Hosp 1, Hefei 230022, Anhui, Peoples R China 5.Univ Sci & Technol China, Dept Pharm, Affiliated Hosp 1, Hefei 230031, Anhui, Peoples R China 6.Anhui Med Univ, Dept Anesthesiol, Affiliated Hosp 1, Hefei 230022, Anhui, Peoples R China
推荐引用方式 GB/T 7714	Sun, Tao,Yu, Shujun,Song, Xuegang,et al. Cold Plasma Irradiation Regulates Inflammation and Oxidative Stress in Human Bronchial Epithelial Cells and Human Non-Small Cell Lung Carcinoma[J]. RADIATION RESEARCH,2022,197.
APA	Sun, Tao.,Yu, Shujun.,Song, Xuegang.,Zhang, Jin.,Bao, Qin.,...&Ni, Guohua.(2022).Cold Plasma Irradiation Regulates Inflammation and Oxidative Stress in Human Bronchial Epithelial Cells and Human Non-Small Cell Lung Carcinoma.RADIATION RESEARCH,197.
MLA	Sun, Tao,et al."Cold Plasma Irradiation Regulates Inflammation and Oxidative Stress in Human Bronchial Epithelial Cells and Human Non-Small Cell Lung Carcinoma".RADIATION RESEARCH 197(2022).