Adjusted Log-rank Test with Double Inverse Weighting under Dependent Censoring

doi:10.1007/s10114-021-0050-1

CORC > 数学与系统科学研究院 > 中国科学院数学与系统科学研究院 > 应用数学研究所

	Adjusted Log-rank Test with Double Inverse Weighting under Dependent Censoring
	Guo, Yi Min 2,3; Zhou, Jie 1; Sun, Liu Quan 2,3
刊名	ACTA MATHEMATICA SINICA-ENGLISH SERIES
	2021-10-01
卷号	37 期号:10 页码:1573-1585
关键词	Adjusted log-rank test dependent censoring double inverse weighting survival data
ISSN号	1439-8516
DOI	10.1007/s10114-021-0050-1
英文摘要	It is a common issue to compare treatment-specific survival and the weighted log-rank test is the most popular method for group comparison. However, in observational studies, treatments and censoring times are usually not independent, which invalidates the weighted log-rank tests. In this paper, we propose adjusted weighted log-rank tests in the presence of non-random treatment assignment and dependent censoring. A double-inverse weighted technique is developed to adjust the weighted log-rank tests. Specifically, inverse probabilities of treatment and censoring weighting are involved to balance the baseline treatment assignment and to overcome dependent censoring, respectively. We derive the asymptotic distribution of the proposed adjusted tests under the null hypothesis, and propose a method to obtain the critical values. Simulation studies show that the adjusted log-rank tests have correct sizes whereas the traditional weighted log-rank tests may fail in the presence of non-random treatment assignment and dependent censoring. An application to oropharyngeal carcinoma data from the Radiation Therapy Oncology Group is provided for illustration.
资助项目	Beijing Municipal Education Commission[KM202010028017] ; National Natural Science Foundation of China[11771431] ; National Natural Science Foundation of China[11690015] ; Key Laboratory of RCSDS, CAS[2008DP173182] ; Academy for Multidisciplinary Studies of Capital Normal University
WOS研究方向	Mathematics
语种	英语
出版者	SPRINGER HEIDELBERG
WOS记录号	WOS:000707010700008
内容类型	期刊论文
源URL	[http://ir.amss.ac.cn/handle/2S8OKBNM/59380]
专题	应用数学研究所
通讯作者	Zhou, Jie
作者单位	1.Capital Normal Univ, Sch Math Sci, Beijing 100048, Peoples R China 2.Chinese Acad Sci, Acad Math & Syst Sci, Inst Appl Math, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Guo, Yi Min,Zhou, Jie,Sun, Liu Quan. Adjusted Log-rank Test with Double Inverse Weighting under Dependent Censoring[J]. ACTA MATHEMATICA SINICA-ENGLISH SERIES,2021,37(10):1573-1585.
APA	Guo, Yi Min,Zhou, Jie,&Sun, Liu Quan.(2021).Adjusted Log-rank Test with Double Inverse Weighting under Dependent Censoring.ACTA MATHEMATICA SINICA-ENGLISH SERIES,37(10),1573-1585.
MLA	Guo, Yi Min,et al."Adjusted Log-rank Test with Double Inverse Weighting under Dependent Censoring".ACTA MATHEMATICA SINICA-ENGLISH SERIES 37.10(2021):1573-1585.