Mixture proportional hazards cure model with latent variables

doi:10.1002/sim.9200

CORC > 数学与系统科学研究院 > 中国科学院数学与系统科学研究院 > 应用数学研究所

	Mixture proportional hazards cure model with latent variables
	He, Haijin 4; Han, Dongxiao 2,3; Song, Xinyuan 1; Sun, Liuquan 5
刊名	STATISTICS IN MEDICINE
	2021-09-15
页码	15
关键词	cure model factor analysis latent variables logistic regression proportional hazards model
ISSN号	0277-6715
DOI	10.1002/sim.9200
英文摘要	A mixture proportional hazards cure model with latent variables is proposed. The proposed model assesses the effects of the observed and latent risk factors on the hazards of uncured subjects and the cure rate through a proportional hazards model and a logistic model, respectively. Factor analysis is employed to measure the latent variables through correlated multiple indicators. Maximum likelihood estimation is performed through a Gaussian quadratic technique that approximates the integration over the latent variables. A piecewise constant function is used for the unspecified baseline hazard of uncured subjects. The proposed method can be conveniently implemented by using SAS Proc NLMIXED. Simulation studies are conducted to evaluate the performance of the proposed approach. An application to a study concerning the risk factors of chronic kidney disease for type 2 diabetic patients is provided.
资助项目	Fundamental Research Funds for the Central Universities, Nankai University[9920200110] ; National Natural Science Foundation of China (NSFC)[11701387] ; Natural Science Foundation of Guangdong Province of China[2019A1515011917] ; Natural Science Foundation of Shenzhen[JCYJ20190808173603590] ; Research Grant Council of the HKSAR[14301918] ; Research Grant Council of the HKSAR[14302519] ; Chinese University of Hong Kong ; NSFC[11771431] ; NSFC[11690015] ; Key Laboratory of RCSDS, CAS[2008DP173182]
WOS研究方向	Mathematical & Computational Biology ; Public, Environmental & Occupational Health ; Medical Informatics ; Research & Experimental Medicine ; Mathematics
语种	英语
出版者	WILEY
WOS记录号	WOS:000696099200001
内容类型	期刊论文
源URL	[http://ir.amss.ac.cn/handle/2S8OKBNM/59260]
专题	应用数学研究所
通讯作者	Han, Dongxiao
作者单位	1.Chinese Univ Hong Kong, Dept Stat, Hong Kong, Peoples R China 2.Nankai Univ, KLMDASR, Tianjin, Peoples R China 3.Nankai Univ, Sch Stat & Data Sci, LPMC, Tianjin, Peoples R China 4.Shenzhen Univ, Coll Math & Stat, Shenzhen, Peoples R China 5.Chinese Acad Sci, Acad Math & Syst Sci, Inst Appl Math, Beijing, Peoples R China
推荐引用方式 GB/T 7714	He, Haijin,Han, Dongxiao,Song, Xinyuan,et al. Mixture proportional hazards cure model with latent variables[J]. STATISTICS IN MEDICINE,2021:15.
APA	He, Haijin,Han, Dongxiao,Song, Xinyuan,&Sun, Liuquan.(2021).Mixture proportional hazards cure model with latent variables.STATISTICS IN MEDICINE,15.
MLA	He, Haijin,et al."Mixture proportional hazards cure model with latent variables".STATISTICS IN MEDICINE (2021):15.