Ten-Input Cube Root Logic Computation with Rational Designed DNA Nanoswitches Coupled with DNA Strand Displacement Process

doi:10.1021/acsami.9b15180

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	Ten-Input Cube Root Logic Computation with Rational Designed DNA Nanoswitches Coupled with DNA Strand Displacement Process
	C. Y. Zhou,H. M. Geng,P. F. Wang and C. L. Guo
刊名	Acs Applied Materials & Interfaces
	2020
卷号	12 期号:2 页码:2601-2606
ISSN号	1944-8244
DOI	10.1021/acsami.9b15180
英文摘要	The predictability of Watson-Crick base pairing provides a unique structural programmability to DNAs, promoting a facile design of bimolecular reactions that perform computation. However, most of the current architectures could only implement limited logical circuits and are incapable of handling more complex mathematical operations, thus limiting computing devices from advancing to the next-stage functional complexity. Here, by designing a multifunctional DNA-based reaction platform coupled with multiple fluorescent substrates as output reporters, we construct, for the first time, a logic circuit that can compute the cube root of a 10-bit binary number (within the decimal number 1000). This relatively large-scale logic system with 10 inputs and four outputs showcases the power of DNAs in the field of biological computing and will potentially open up a new horizon for designing novel functional devices and complex computing circuits and bringing breakthroughs in biocomputing.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.ciomp.ac.cn/handle/181722/64947]
专题	中国科学院长春光学精密机械与物理研究所
推荐引用方式 GB/T 7714	C. Y. Zhou,H. M. Geng,P. F. Wang and C. L. Guo. Ten-Input Cube Root Logic Computation with Rational Designed DNA Nanoswitches Coupled with DNA Strand Displacement Process[J]. Acs Applied Materials & Interfaces,2020,12(2):2601-2606.
APA	C. Y. Zhou,H. M. Geng,P. F. Wang and C. L. Guo.(2020).Ten-Input Cube Root Logic Computation with Rational Designed DNA Nanoswitches Coupled with DNA Strand Displacement Process.Acs Applied Materials & Interfaces,12(2),2601-2606.
MLA	C. Y. Zhou,H. M. Geng,P. F. Wang and C. L. Guo."Ten-Input Cube Root Logic Computation with Rational Designed DNA Nanoswitches Coupled with DNA Strand Displacement Process".Acs Applied Materials & Interfaces 12.2(2020):2601-2606.