Three new secoiridoids, swermacrolactones A-C and anti-hepatitis B virus activity from Swertia macrosperma

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Three new secoiridoids, swermacrolactones A-C and anti-hepatitis B virus activity from Swertia macrosperma
	Wang, Hong-Ling 1,2; Geng, Chang-An1 ; Ma, Yun-Bao 1; Zhang, Xue-Mei1 ; Chen, Ji-Jun1
刊名	FITOTERAPIA
	2013-09-01
卷号	89 页码:183-187
关键词	Secoiridoids Swermacrolactones A-C Anti-HBV activity Swertia macrosperma Gentianaceae
ISSN号	0367-326X
通讯作者	Chen, JJ (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China. ; chenjj@mail.kib.ac.cn
英文摘要	Three new secoiridoids, swermacrolactones A-C (1-3), together with fourteen known compounds were isolated from Swertia macrosperma. Their structures were elucidated based on extensive spectroscopic analyses (IR, UV, MS, 1D and 2D NMR). By anti-HBV assay on the Hep G 2.2.15 cell line in vitro, the most active compound, luteolin (9), inhibited the secretion of hepatitis B virus surface antigen (HBsAg) and hepatitis B virus e antigen (HBeAg) with IC50 values of 0.02 and 0.02 mM, respectively. (c) 2013 Elsevier B.V. All rights reserved.
学科主题	Chemistry, Medicinal; Pharmacology & Pharmacy
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]	Pharmacology & Pharmacy
关键词[WOS]	JAPONICA MAKINO ; ANGUSTIFOLIA ; MILEENSIS
收录类别	SCI
资助信息	National Natural Science Foundation of China for Distinguished Young Scholars [81025023]; National Natural Science Foundation of China and Yunnan Province [U0832603]; West Light Foundation of the Chinese Academy of Sciences; International Foundation for Science, Stockholm, Sweden [F/5202-1]
语种	英语
WOS记录号	WOS:000323856500020
公开日期	2013-10-16
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/16677]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Wang, Hong-Ling,Geng, Chang-An,Ma, Yun-Bao,et al. Three new secoiridoids, swermacrolactones A-C and anti-hepatitis B virus activity from Swertia macrosperma[J]. FITOTERAPIA,2013,89:183-187.
APA	Wang, Hong-Ling,Geng, Chang-An,Ma, Yun-Bao,Zhang, Xue-Mei,&Chen, Ji-Jun.(2013).Three new secoiridoids, swermacrolactones A-C and anti-hepatitis B virus activity from Swertia macrosperma.FITOTERAPIA,89,183-187.
MLA	Wang, Hong-Ling,et al."Three new secoiridoids, swermacrolactones A-C and anti-hepatitis B virus activity from Swertia macrosperma".FITOTERAPIA 89(2013):183-187.