Aiming at the lack of reliable gradual fault detection and abnormal condition alarm and evaluation ability in the plasticizing process of single-base gun propellant, a fault detection and diagnosis method based on normalized mutual information weighted multiway principal component analysis (NMI-WMPCA) under limited batch samples modelling was proposed. In this method, the differences of coupling correlation among multi-dimensional process variables and the coupling characteristics of linear and nonlinear relationships in the process are considered. NMI-WMPCA utilizes the generalization ability of a multi-model to establish an accurate fault detection model in limited batch samples, and adopts fault diagnosis methods based on a multi-model SPE statistic contribution plot to identify the fault source. The experimental results demonstrate that the proposed method is effective, which can realize the rapid detection and diagnosis of multiple faults in the plasticizing process. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.