Aligned Organization of Synapses and Mitochondria in Auditory Hair Cells

doi:10.1007/s12264-021-00801-w

CORC > 自动化研究所 > 中国科学院自动化研究所 > 类脑智能研究中心 > 微观重建与智能分析

	Aligned Organization of Synapses and Mitochondria in Auditory Hair Cells
	Liu, Jing 7,8,9; Wang, Shengxiong 1,4; Lu, Yan 1,2,5,6; Wang, Haoyu 1,2,5,6; Wang, Fangfang 1; Qiu, Miaoxin 4; Xie, Qiwei 3; Han, Hua 7,8,9; Hua, Yunfeng 1,2,5,6
刊名	NEUROSCIENCE BULLETIN
	2021-11-27
页码	14
关键词	Inner hair cell Ribbon synapse Mitochondrial network Volume electron microscopy AI-based image processing
ISSN号	1673-7067
DOI	10.1007/s12264-021-00801-w
通讯作者	Han, Hua(hua.han@ia.ac.cn) ; Hua, Yunfeng(yunfeng.hua@shsmu.edu.cn)
英文摘要	Recent studies have revealed great functional and structural heterogeneity in the ribbon-type synapses at the basolateral pole of the isopotential inner hair cell (IHC). This feature is believed to be critical for audition over a wide dynamic range, but whether the spatial gradient of ribbon morphology is fine-tuned in each IHC and how the mitochondrial network is organized to meet local energy demands of synaptic transmission remain unclear. By means of three-dimensional electron microscopy and artificial intelligence-based algorithms, we demonstrated the cell-wide structural quantification of ribbons and mitochondria in mature mid-cochlear IHCs of mice. We found that adjacent IHCs in staggered pairs differ substantially in cell body shape and ribbon morphology gradient as well as mitochondrial organization. Moreover, our analysis argues for a location-specific arrangement of correlated ribbon and mitochondrial function at the basolateral IHC pole.
资助项目	National Natural Science Foundation of China[81800901] ; Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning[QD2018015] ; Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases[14DZ2260300] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB32030200] ; Bureau of International Cooperation, Chinese Academy of Sciences[153D31KYSB20170059]
WOS关键词	QUANTITATIVE-ANALYSIS ; RESPONSE PROPERTIES ; NERVE FIBERS ; CAT COCHLEA ; AFFERENT ; RECONSTRUCTION ; HETEROGENEITY ; INNERVATION ; GRADIENTS ; VESICLES
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000722958700001
资助机构	National Natural Science Foundation of China ; Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning ; Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Bureau of International Cooperation, Chinese Academy of Sciences
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/46548]
专题	类脑智能研究中心_微观重建与智能分析
通讯作者	Han, Hua; Hua, Yunfeng
作者单位	1.Shanghai Jiao Tong Univ, Peoples Hosp 9, Shanghai Inst Precis Med, Sch Med, Shanghai 200125, Peoples R China 2.Shanghai Key Lab Translat Med Ear & Nose Dis, Shanghai 200125, Peoples R China 3.Beijing Univ Technol, Res Base Beijing Modern Mfg Dev, Beijing 100124, Peoples R China 4.Tongji Univ, Putuo Peoples Hosp, Shanghai 200060, Peoples R China 5.Shanghai Jiao Tong Univ, Ear Inst, Sch Med, Shanghai 200125, Peoples R China 6.Shanghai Ninth Peoples Hosp, Dept OtolaryngologyHead & Neck Surg, Shanghai 200125, Peoples R China 7.CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai 200031, Peoples R China 8.Univ Chinese Acad Sci, Sch Artificial Intelligence, Sch Future Technol, Beijing 101408, Peoples R China 9.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Liu, Jing,Wang, Shengxiong,Lu, Yan,et al. Aligned Organization of Synapses and Mitochondria in Auditory Hair Cells[J]. NEUROSCIENCE BULLETIN,2021:14.
APA	Liu, Jing.,Wang, Shengxiong.,Lu, Yan.,Wang, Haoyu.,Wang, Fangfang.,...&Hua, Yunfeng.(2021).Aligned Organization of Synapses and Mitochondria in Auditory Hair Cells.NEUROSCIENCE BULLETIN,14.
MLA	Liu, Jing,et al."Aligned Organization of Synapses and Mitochondria in Auditory Hair Cells".NEUROSCIENCE BULLETIN (2021):14.