Photochemical Synthesis of Nonplanar Small Molecules with Ultrafast Nonradiative Decay for Highly Efficient Phototheranostics

doi:10.1002/adma.202102799

	Photochemical Synthesis of Nonplanar Small Molecules with Ultrafast Nonradiative Decay for Highly Efficient Phototheranostics
	Li, Xiaozhen 1,2; Zhang, Di 3,4; Lu, Guihong 5; He, Tingchao 6; Wan, Yingpeng 1,2; Tse, Man-Kit 3; Ren, Can 6; Wang, Pengfei 2,7; Li, Shengliang 1,8; Luo, Jingdong 3,4
刊名	ADVANCED MATERIALS
	2021-07-28
页码	10
关键词	molecular motion nonplanar small molecules photoacoustic imaging photochemical reaction photothermal therapy
ISSN号	0935-9648
DOI	10.1002/adma.202102799
英文摘要	There has been much recent progress in the development of photothermal agents (PTAs) for biomedical and energy applications. Synthesis of organic PTAs typically involves noble metal catalysts and high temperatures. On the other hand, photochemical synthesis, as an alternative and green chemical technology, has obvious merits such as low cost, energy efficiency, and high yields. However, photochemical reactions have rarely been employed for the synthesis of PTAs. Herein, a facile and high-yield photochemical reaction is exploited for synthesizing nonplanar small molecules (NSMs) containing strong Michler's base donors and a tricyanoquinodimethane acceptor as high-performance PTAs. The synthesized NSMs show interesting photophysical properties including good absorption for photons of over 1000 nm wavelength, high near-infrared extinction coefficients, and excellent photothermal performance. Upon assembling the NSMs into nanoparticles (NSMN), they exhibit good biocompatibility, high photostability, and excellent photothermal conversion efficiency of 75%. Excited-state dynamic studies reveal that the NSMN has ultrafast nonradiative decay after photoexcitation. With these unique properties, the NSMN achieves efficient in vivo photoacoustic imaging and photothermal tumor ablation. This work demonstrates the superior potential of photochemical reactions for the synthesis of high-performance molecular PTAs.
资助项目	University Grants Committee/Research Grants Council of the Hong Kong Special Administrative Region via the GRF project[CityU 11300320] ; Natural Science Foundation of China[21975213] ; City University of Hong Kong[9610454] ; City University of Hong Kong[9680263] ; City University of Hong Kong[9610389] ; General Research Fund of HKSAR (RGC)[11306320] ; Shenzhen Science & Technology Innovation Committee[JCYJ20180507181718203] ; National Natural Science Foundation of China[32000988] ; China Postdoctoral Science Foundation[2019TQ0212] ; China Postdoctoral Science Foundation[2020M672832]
WOS关键词	SEMICONDUCTING POLYMER NANOPARTICLES ; PHOTOTHERMAL MATERIALS ; ORGANIC NANOPARTICLES ; CARBON NANOTUBES ; PERFORMANCE ; CHROMOPHORES ; AGENTS
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000678193600001
资助机构	University Grants Committee/Research Grants Council of the Hong Kong Special Administrative Region via the GRF project ; Natural Science Foundation of China ; City University of Hong Kong ; General Research Fund of HKSAR (RGC) ; Shenzhen Science & Technology Innovation Committee ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/49543]
专题	中国科学院过程工程研究所
通讯作者	Lu, Guihong; Li, Shengliang; Luo, Jingdong; Lee, Chun-Sing
作者单位	1.City Univ Hong Kong, Dept Chem, Ctr Super Diamond & Adv Films COSDAF, Kowloon, 83 Tat Chee Ave, Hong Kong, Peoples R China 2.City Univ Hong Kong, Joint Lab Nanoorgan Funct Mat & Devices TIPC & Ci, Kowloon, 83 Tat Chee Ave, Hong Kong, Peoples R China 3.City Univ Hong Kong, Dept Chem, Kowloon, 83 Tat Chee Ave, Hong Kong, Peoples R China 4.City Univ Hong Kong, Shenzhen Res Inst, Shenzhen 518057, Peoples R China 5.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, 1 North 2nd St, Beijing 100190, Peoples R China 6.Shenzhen Univ, Coll Phys & Optoelect Engn, Shenzhen 518060, Peoples R China 7.Chinese Acad Sci, Tech Inst Phys & Chem, Beijing 100190, Peoples R China 8.Soochow Univ, Coll Pharmaceut Sci, Suzhou 215123, Peoples R China
推荐引用方式 GB/T 7714	Li, Xiaozhen,Zhang, Di,Lu, Guihong,et al. Photochemical Synthesis of Nonplanar Small Molecules with Ultrafast Nonradiative Decay for Highly Efficient Phototheranostics[J]. ADVANCED MATERIALS,2021:10.
APA	Li, Xiaozhen.,Zhang, Di.,Lu, Guihong.,He, Tingchao.,Wan, Yingpeng.,...&Lee, Chun-Sing.(2021).Photochemical Synthesis of Nonplanar Small Molecules with Ultrafast Nonradiative Decay for Highly Efficient Phototheranostics.ADVANCED MATERIALS,10.
MLA	Li, Xiaozhen,et al."Photochemical Synthesis of Nonplanar Small Molecules with Ultrafast Nonradiative Decay for Highly Efficient Phototheranostics".ADVANCED MATERIALS (2021):10.