Tumor Exosomes Reprogrammed by Low pH Are Efficient Targeting Vehicles for Smart Drug Delivery and Personalized Therapy against their Homologous Tumor

doi:10.1002/advs.202002787

	Tumor Exosomes Reprogrammed by Low pH Are Efficient Targeting Vehicles for Smart Drug Delivery and Personalized Therapy against their Homologous Tumor
	Gong, Changguo 1; Zhang, Xiao 2; Shi, Min 1; Li, Feng 2,3; Wang, Shuang 2; Wang, Yan 1,2; Wang, Yugang 3; Wei, Wei 2,3; Ma, Guanghui 2,3
刊名	ADVANCED SCIENCE
	2021-03-16
页码	13
关键词	combination therapy lipids rearrangement low pH reprogramming patient‐ derived xenografts tumor exosomes
DOI	10.1002/advs.202002787
英文摘要	As membrane-bound extracellular vesicles, exosomes have targeting ability for specific cell types, and the cellular environment strongly impacts their content and uptake efficiency. Inspired by these natural properties, the impacts of various cellular stress conditions on the uptake efficiency of tumor iterated exosomes are evaluated, and low-pH treatment caused increased uptake efficiency and retained cell-type specificity is found. Lipidomics analyses and molecular dynamics simulations reveal a glycerolipid self-aggregation-based mechanism for the enhanced homologous uptake. Furthermore, these low-pH reprogrammed exosomes are developed into a smart drug delivery platform, which is capable of specifically targeting tumor cells and selectively releasing diverse chemodrugs in response to the exosome rupture by the near-infrared irradiance-triggered burst of reactive oxygen species. This platform exerts safe and enhanced antitumor effects demonstrated by multiple model mice experiments. These results open a new avenue to reprogram exosomes for smart drug delivery and potentially personalized therapy against their homologous tumor.
资助项目	Innovative Research Group Project of the National Natural Science Foundation of China[21821005] ; National Natural Science Foundation of China[81871912] ; National Natural Science Foundation of China[81970530] ; National Key R&D Program of China[2017YFA0207900] ; Chinese Academy of Sciences[XDB29040303] ; Shanghai Municipal Health Bureau Key Disciplines Grant[ZK2019C012]
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	WILEY
WOS记录号	WOS:000629229800001
资助机构	Innovative Research Group Project of the National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; Chinese Academy of Sciences ; Shanghai Municipal Health Bureau Key Disciplines Grant
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/48018]
专题	中国科学院过程工程研究所
通讯作者	Wang, Yugang; Wei, Wei; Ma, Guanghui
作者单位	1.Shanghai Jiao Tong Univ, Sch Med, Tongren Hosp, Dept Gastroenterol, 1111 Xianxia Rd, Shanghai 200336, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 Bei Er Tiao, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Sch Chem Engn, 19A Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Gong, Changguo,Zhang, Xiao,Shi, Min,et al. Tumor Exosomes Reprogrammed by Low pH Are Efficient Targeting Vehicles for Smart Drug Delivery and Personalized Therapy against their Homologous Tumor[J]. ADVANCED SCIENCE,2021:13.
APA	Gong, Changguo.,Zhang, Xiao.,Shi, Min.,Li, Feng.,Wang, Shuang.,...&Ma, Guanghui.(2021).Tumor Exosomes Reprogrammed by Low pH Are Efficient Targeting Vehicles for Smart Drug Delivery and Personalized Therapy against their Homologous Tumor.ADVANCED SCIENCE,13.
MLA	Gong, Changguo,et al."Tumor Exosomes Reprogrammed by Low pH Are Efficient Targeting Vehicles for Smart Drug Delivery and Personalized Therapy against their Homologous Tumor".ADVANCED SCIENCE (2021):13.