A High-Resolution Ternary Model Demonstrates How PEGylated 2D Nanomaterial Stimulates Integrin alpha(v)beta(8) on Cell Membrane | |
Zhang, Xiao1; Ding, Zhaowen1; Ma, Guanghui1,2; Wei, Wei1,2 | |
刊名 | ADVANCED SCIENCE |
2021-03-23 | |
页码 | 12 |
关键词 | Conformational Changes Integrin Activation Molecular Dynamics Simulations Passivated 2d Nanomaterials Ternary Model |
DOI | 10.1002/advs.202004506 |
英文摘要 | Bio-nano interfaces are integral to all applications of nanomaterials in biomedicine. In addition to peptide-ligand-functionalized nanomaterials, passivation on 2D nanomaterials has emerged as a new regulatory factor for integrin activation. However, the mechanisms underlying such ligand-independent processes are poorly understood. Here, using graphene oxide passivated with polyethylene glycol (GO-PEG) as a test bed, a ternary simulation model is constructed that also includes a membrane and both subunits of integrin alpha(v)beta(8) to characterize GO-PEG-mediated integrin activation on the cell membrane in a ligand-independent manner. Combined with the experimental findings, production simulations of the ternary model show a three-phase mechanotransduction process in the vertical interaction mode. Specifically, GO-PEG first induces lipid aggregation-mediated integrin proximity, followed by transmembrane domain rotation and separation, leading to the extension and activation of extracellular domains. Thus, this study presents a complete picture of the interaction between passivated 2D nanomaterials and cell membranes to mediate integrin activation, and provides insights into the potential de novo design and rational use of novel desirable nanomaterials at diverse bio-nano interfaces. |
资助项目 | National Natural Science Foundation of China[21821005] ; National Natural Science Foundation of China[32030062] ; National Natural Science Foundation of China[U2001224] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB29040303] ; National Key R&D Program of China[2017YFA0207900] |
WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
语种 | 英语 |
出版者 | WILEY |
WOS记录号 | WOS:000631540900001 |
资助机构 | National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Key R&D Program of China |
内容类型 | 期刊论文 |
源URL | [http://ir.ipe.ac.cn/handle/122111/47896] |
专题 | 中国科学院过程工程研究所 |
通讯作者 | Wei, Wei |
作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 Bei Er Tiao, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem Engn, 19A Yuquan Rd, Beijing 100049, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Xiao,Ding, Zhaowen,Ma, Guanghui,et al. A High-Resolution Ternary Model Demonstrates How PEGylated 2D Nanomaterial Stimulates Integrin alpha(v)beta(8) on Cell Membrane[J]. ADVANCED SCIENCE,2021:12. |
APA | Zhang, Xiao,Ding, Zhaowen,Ma, Guanghui,&Wei, Wei.(2021).A High-Resolution Ternary Model Demonstrates How PEGylated 2D Nanomaterial Stimulates Integrin alpha(v)beta(8) on Cell Membrane.ADVANCED SCIENCE,12. |
MLA | Zhang, Xiao,et al."A High-Resolution Ternary Model Demonstrates How PEGylated 2D Nanomaterial Stimulates Integrin alpha(v)beta(8) on Cell Membrane".ADVANCED SCIENCE (2021):12. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论