Yeast-Based A beta 1-15 Vaccine Elicits Strong Immunogenicity and Attenuates Neuropathology and Cognitive Deficits in Alzheimer's Disease Transgenic Mice

doi:10.3390/vaccines8030351

	Yeast-Based A beta 1-15 Vaccine Elicits Strong Immunogenicity and Attenuates Neuropathology and Cognitive Deficits in Alzheimer's Disease Transgenic Mice
	Liu, Dong-qun 1,2; Lu, Shuai 2; Zhang, Lun 1,2; Huang, Ya-ru 1,2; Ji, Mei 1,2; Sun, Xiao-ying 1,2; Liu, Xiao-ge 1,2; Liu, Rui-tian 2
刊名	VACCINES
	2020-09-01
卷号	8 期号:3 页码:13
关键词	Alzheimer's disease beta-amyloid active immunotherapy yeast vaccine
DOI	10.3390/vaccines8030351
英文摘要	Immunotherapy focusing on reducing the amyloid-beta (A beta) burden is a promising treatment strategy for Alzheimer's disease (AD). Many clinical studies on AD immunotherapies have failed due to low safety and efficacy, calling for a highly potent AD vaccine which induces sufficient antibody titer while avoiding side effects. Here, we designed a yeast-based vaccine Y-5A15 comprising five copies of A beta 1-15 displayed on the surface of yeast cell wall, and we subcutaneously immunized APP/PS1 mice three times. Our results demonstrated that the Y-5A15 remarkably enhanced the A beta epitope immunogenicity and elicited high antibody titers against A beta in AD mice. Importantly, Y-5A15 vaccination successfully reduced A beta levels, plaque burden and glial activation, rescued synaptic deficits and significantly ameliorated memory and cognitive decline in APP/PS1 transgenic mice, suggesting that the yeast-based A beta epitope vaccine has a promising potency for the treatment of AD.
资助项目	National Natural Science Foundation of China[31401158] ; National Natural Science Foundation of China[81972444]
WOS关键词	AMYLOID-BETA-PROTEIN ; CROSS-PRESENTATION ; FOLLOW-UP ; IMMUNIZATION ; ANTIBODIES ; PATHOLOGY ; PEPTIDE ; PLAQUES ; AN1792 ; MODEL
WOS研究方向	Immunology ; Research & Experimental Medicine
语种	英语
出版者	MDPI
WOS记录号	WOS:000579955200001
资助机构	National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/42478]
专题	中国科学院过程工程研究所
通讯作者	Liu, Rui-tian
作者单位	1.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Liu, Dong-qun,Lu, Shuai,Zhang, Lun,et al. Yeast-Based A beta 1-15 Vaccine Elicits Strong Immunogenicity and Attenuates Neuropathology and Cognitive Deficits in Alzheimer's Disease Transgenic Mice[J]. VACCINES,2020,8(3):13.
APA	Liu, Dong-qun.,Lu, Shuai.,Zhang, Lun.,Huang, Ya-ru.,Ji, Mei.,...&Liu, Rui-tian.(2020).Yeast-Based A beta 1-15 Vaccine Elicits Strong Immunogenicity and Attenuates Neuropathology and Cognitive Deficits in Alzheimer's Disease Transgenic Mice.VACCINES,8(3),13.
MLA	Liu, Dong-qun,et al."Yeast-Based A beta 1-15 Vaccine Elicits Strong Immunogenicity and Attenuates Neuropathology and Cognitive Deficits in Alzheimer's Disease Transgenic Mice".VACCINES 8.3(2020):13.