Human Motion Driven Self-Powered Photodynamic System for Long-Term Autonomous Cancer Therapy

doi:10.1021/acsnano.0c00675

	Human Motion Driven Self-Powered Photodynamic System for Long-Term Autonomous Cancer Therapy
	Liu, Zhuo 1,3; Xu, Lingling 3,4; Zheng, Qiang 3,4; Kang, Yong 4,6; Shi, Bojing 1,3; Jiang, Dongjie 3,4; Li, Hu 1,3; Qu, Xuecheng 3,4; Fan, Yubo 1,2; Wang, Zhong Lin 3,4,5
刊名	ACS NANO
	2020-07-28
卷号	14 期号:7 页码:8074-8083
关键词	human motion self-powered device photodynamic therapy cancer therapy wearable
ISSN号	1936-0851
DOI	10.1021/acsnano.0c00675
英文摘要	Long-term and low-dose photodynamic therapy for treating tumors requires a sustainable energy supply. The power source technology of batteries and wireless charging for driving a light-emitting diode (LED) may cause inconveniences during treatment. In addition, the development of telemedicine and Internet medicine put forward higher demands on treatment methods, such as better patient compliance and autonomous management. Here, we show a self-powered photodynamic therapy (s-PDT) system with two different irradiation modes that can be autonomously managed by or death patients. The as-fabricated s-PDT system based on a twinning structured piezoelectric nanogenerator is powered by energy harvested from body motion and realizes effective tumor tissue killing and inhibition. As demonstrated at the cellular level, the s-PDT system can significantly suppress tumor cell growth with the pulsed light stimulation mode. When the miniature LED was implanted subcutaneously in mice with transplanted tumors, the s-PDT system led to significant antitumor effects by irradiation with intermittent continuous light stimulation mode for 12 days, and an 87.46% tumor inhibition rate was obtained. This innovative s-PDT system combined with two treatment modes may provide a great opportunity to develop wearable/implantable and self-controllable devices for long-term photodynamic therapy, which would be a promising method for clinical cancer treatment.
资助项目	National Key R&D project from Minister of Science and Technology, China[2016YFA0202703] ; National Natural Science Foundation of China[61875015] ; National Natural Science Foundation of China[81601629] ; National Natural Science Foundation of China[21801019] ; National Natural Science Foundation of China[11421202] ; National Natural Science Foundation of China[11827803] ; 111 Project[B13003] ; Beijing Natural Science Foundation[7204333] ; Key-Area Research and Development Program of Guangdong Province[2018B030331001] ; University of Chinese Academy of Sciences[Y954019] ; National Youth Talent Support Program
WOS关键词	LIGHT DELIVERY ; PHOTOSENSITIZER ; TUMOR ; PROLIFERATION ; PACEMAKER
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000557762800033
资助机构	National Key R&D project from Minister of Science and Technology, China ; National Natural Science Foundation of China ; 111 Project ; Beijing Natural Science Foundation ; Key-Area Research and Development Program of Guangdong Province ; University of Chinese Academy of Sciences ; National Youth Talent Support Program
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/41796]
专题	中国科学院过程工程研究所
通讯作者	Fan, Yubo; Wang, Zhong Lin; Li, Zhou
作者单位	1.Beihang Univ, Beijing Adv Innovat Ctr Biomed Engn, Key Lab Biomech & Mechanobiol, Minist Educ,Sch Biol Sci & Med Engn, Beijing 100083, Peoples R China 2.Natl Res Ctr Rehabil Tech Aids, Beijing 100176, Peoples R China 3.Chinese Acad Sci, CAS Ctr Excellence Nanosci, Beijing Key Lab Micronano Energy & Sensor, Beijing Inst Nanoenergy & Nanosyst, Beijing 100083, Peoples R China 4.Univ Chinese Acad Sci, Sch Nanosci & Technol, Beijing 100049, Peoples R China 5.Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA 6.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Liu, Zhuo,Xu, Lingling,Zheng, Qiang,et al. Human Motion Driven Self-Powered Photodynamic System for Long-Term Autonomous Cancer Therapy[J]. ACS NANO,2020,14(7):8074-8083.
APA	Liu, Zhuo.,Xu, Lingling.,Zheng, Qiang.,Kang, Yong.,Shi, Bojing.,...&Li, Zhou.(2020).Human Motion Driven Self-Powered Photodynamic System for Long-Term Autonomous Cancer Therapy.ACS NANO,14(7),8074-8083.
MLA	Liu, Zhuo,et al."Human Motion Driven Self-Powered Photodynamic System for Long-Term Autonomous Cancer Therapy".ACS NANO 14.7(2020):8074-8083.