The Toxicity and Polymorphism of beta-Amyloid Oligomers

doi:10.3390/ijms21124477

	The Toxicity and Polymorphism of beta-Amyloid Oligomers
	Huang, Ya-ru 1,2; Liu, Rui-tian 1
刊名	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
	2020-06-01
卷号	21 期号:12 页码:19
关键词	beta-amyloid oligomers Alzheimer's disease polymorphism toxicity aggregation
DOI	10.3390/ijms21124477
英文摘要	It is widely accepted that beta-amyloid oligomers (A beta os) play a key role in the progression of Alzheimer's disease (AD) by inducing neuron damage and cognitive impairment, but A beta os are highly heterogeneous in their size, structure and cytotoxicity, making the corresponding studies tough to carry out. Nevertheless, a number of studies have recently made remarkable progress in the describing the characteristics and pathogenicity of A beta os. We here review the mechanisms by which A beta os exert their neuropathogenesis for AD progression, including receptor binding, cell membrane destruction, mitochondrial damage, Ca(2+)homeostasis dysregulation and tau pathological induction. We also summarize the characteristics and pathogenicity such as the size, morphology and cytotoxicity of dimers, trimers, A beta*56 and spherical oligomers, and suggest that A beta os may play a different role at different phases of AD pathogenesis, resulting in differential consequences on neuronal synaptotoxicity and survival. It is warranted to investigate the temporal sequence of A beta os in AD human brain and examine the relationship between different A beta os and cognitive impairment.
资助项目	National Natural Science Foundation of China[81971610] ; National Natural Science Foundation of China[81971073]
WOS关键词	CELLULAR PRION PROTEIN ; A-BETA ; ALZHEIMERS-DISEASE ; SYNAPTIC PLASTICITY ; MOUSE MODEL ; COGNITIVE IMPAIRMENT ; TAU PHOSPHORYLATION ; ADRENERGIC-RECEPTOR ; PRECURSOR PROTEIN ; MEMORY DEFICITS
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	MDPI
WOS记录号	WOS:000550123500001
资助机构	National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/41439]
专题	中国科学院过程工程研究所
通讯作者	Liu, Rui-tian
作者单位	1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Huang, Ya-ru,Liu, Rui-tian. The Toxicity and Polymorphism of beta-Amyloid Oligomers[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2020,21(12):19.
APA	Huang, Ya-ru,&Liu, Rui-tian.(2020).The Toxicity and Polymorphism of beta-Amyloid Oligomers.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,21(12),19.
MLA	Huang, Ya-ru,et al."The Toxicity and Polymorphism of beta-Amyloid Oligomers".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 21.12(2020):19.