Catalytic synthesis of methacroleinviathe condensation of formaldehyde and propionaldehyde withl-proline

doi:10.1039/d0gc00726a

	Catalytic synthesis of methacroleinviathe condensation of formaldehyde and propionaldehyde withl-proline
	Yu, Jiayuan 1,2; Jensen, Anker Degn 3; Wang, Lei 2; Li, Chunshan 2; Zhang, Suojiang 2
刊名	GREEN CHEMISTRY
	2020-07-07
卷号	22 期号:13 页码:4222-4230
ISSN号	1463-9262
DOI	10.1039/d0gc00726a
英文摘要	Methacrolein (MAL) is an important chemical for the manufacture of methyl methacrylate and a key monomer in many polymerization reactions. In this study,l-proline was investigated as the catalyst for the aldol condensation of formaldehyde and propionaldehyde to produce MAL. The catalytic activity of the reaction system was closely related to the competition between the main reaction synthesizing MAL and the side reaction producing 2-methyl-2-pentenal, which could be modified by adjusting the operating parameters. The influences of several operating conditions, including temperature, reaction time and water content, on the catalytic performance of the system were systematically studiedviaa series of single-factor experiments, and the optimized reaction conditions were obtained. The mechanistic investigationviaESI-MS indicated that the reaction pathway followed the Mannich route. Experimental and theoretical kinetic analyses of thel-proline-catalyzed aldol condensation reaction were performed, and the reaction orders of the reactants were obtained by regression. The results showed thatl-proline was an efficient catalyst for the production of MALviaaldol condensation under mild conditions.
资助项目	National Natural Science Funds[21878293] ; Science Funds for Creative Research Groups of the National Natural Science Foundation of China[21921005] ; Key Research Program of Frontier Sciences[CAS QYZDB-SSW-SLH022]
WOS关键词	CROSS-ALDOL CONDENSATION ; ASYMMETRIC ALDOL ; MANNICH ; ORGANOCATALYSIS ; ALDEHYDES ; WATER
WOS研究方向	Chemistry ; Science & Technology - Other Topics
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000545862800015
资助机构	National Natural Science Funds ; Science Funds for Creative Research Groups of the National Natural Science Foundation of China ; Key Research Program of Frontier Sciences
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/41341]
专题	中国科学院过程工程研究所
通讯作者	Wang, Lei; Zhang, Suojiang
作者单位	1.Univ Chinese Acad Sci, Sino Danish Coll, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Innovat Acad Green Manufacture, Beijing Key Lab Ion Liquids Clean Proc, CAS Key Lab Green Proc & Engn,State Key Lab Multi, Beijing 100190, Peoples R China 3.Tech Univ Denmark, Dept Chem & Biochem Engn, DK-2800 Lyngby, Denmark
推荐引用方式 GB/T 7714	Yu, Jiayuan,Jensen, Anker Degn,Wang, Lei,et al. Catalytic synthesis of methacroleinviathe condensation of formaldehyde and propionaldehyde withl-proline[J]. GREEN CHEMISTRY,2020,22(13):4222-4230.
APA	Yu, Jiayuan,Jensen, Anker Degn,Wang, Lei,Li, Chunshan,&Zhang, Suojiang.(2020).Catalytic synthesis of methacroleinviathe condensation of formaldehyde and propionaldehyde withl-proline.GREEN CHEMISTRY,22(13),4222-4230.
MLA	Yu, Jiayuan,et al."Catalytic synthesis of methacroleinviathe condensation of formaldehyde and propionaldehyde withl-proline".GREEN CHEMISTRY 22.13(2020):4222-4230.