Double Emulsion-Templated Single-Core PLGA Microcapsules with Narrow Size Distribution and Controllable Structure by Using Premix Membrane Emulsification

doi:10.1002/cnma.202000175

	Double Emulsion-Templated Single-Core PLGA Microcapsules with Narrow Size Distribution and Controllable Structure by Using Premix Membrane Emulsification
	Na, Xiangming 3; Guo, Jianjun 1; Li, Tong 1; Zhou, Weiqing 2,3; Ma, Guanghui 3
刊名	CHEMNANOMAT
	2020-04-29
页码	5
关键词	Double emulsion Membrane emulsification Single-core microcapsule Controllable structures
ISSN号	2199-692X
DOI	10.1002/cnma.202000175
英文摘要	A scalable and versatile strategy was developed for fabrication of double emulsion-templated single-core PLGA microcapsules with narrow size distribution and controllable structure. A single-core water-in-oil-in-water (W-1/O/W-2) double emulsion was generated from two-step premix membrane emulsification, which guaranteed the narrow size distribution and size controllability of emulsion. During a secondary emulsification process, coalescence of W-1 droplets within oil droplet allowed multi-core W-1/O/W-2 double emulsion to spontaneously transform to a single-core one. The osmotic pressure and solvent diffusion rate were used to control the shell-thickness and surface morphology of single-core PLGA microcapsules, respectively. The method proposed in this study could be extended for the fabrication of uniform single-core polymeric microcapsules with controllable structures and size.
资助项目	National Natural Science Foundation of China[21902160] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA16020405] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB29040303]
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000529198200001
资助机构	National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/40393]
专题	中国科学院过程工程研究所
通讯作者	Zhou, Weiqing; Ma, Guanghui
作者单位	1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 North 2nd St, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Stem Cell & Regenerat, 1 North 2nd St, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 North 2nd St, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Na, Xiangming,Guo, Jianjun,Li, Tong,et al. Double Emulsion-Templated Single-Core PLGA Microcapsules with Narrow Size Distribution and Controllable Structure by Using Premix Membrane Emulsification[J]. CHEMNANOMAT,2020:5.
APA	Na, Xiangming,Guo, Jianjun,Li, Tong,Zhou, Weiqing,&Ma, Guanghui.(2020).Double Emulsion-Templated Single-Core PLGA Microcapsules with Narrow Size Distribution and Controllable Structure by Using Premix Membrane Emulsification.CHEMNANOMAT,5.
MLA	Na, Xiangming,et al."Double Emulsion-Templated Single-Core PLGA Microcapsules with Narrow Size Distribution and Controllable Structure by Using Premix Membrane Emulsification".CHEMNANOMAT (2020):5.