Graphene oxide-based nanocomposite enabled highly efficient targeted synergistic therapy for colorectal cancer

doi:10.1016/j.colsurfa.2020.124585

	Graphene oxide-based nanocomposite enabled highly efficient targeted synergistic therapy for colorectal cancer
	Qiu, Zhichao 1,2,3; Hu, Jing 3; Li, Ziwei 1; Yang, Xiaoxue 1; Hu, Jun 1; You, Qingjun 2; Bai, Shuo 4; Mao, Yong 2; Hua, Dong 2; Yin, Jian 1
刊名	COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
	2020-05-20
卷号	593 页码:8
关键词	Graphene oxide GE11 Drug delivery GSH Chemo-photothermal therapy
ISSN号	0927-7757
DOI	10.1016/j.colsurfa.2020.124585
英文摘要	Integrating different therapies into a single nanoplatform has shown great potential for synergistic anti-tumor therapy. In this work, we fabricated the graphene oxide (GO)-based nanosheets loaded with chemotherapeutic drug 5-fluorouracil (5-FU) and modified with GE11, which is an efficient ligand for epidermal growth factor receptor (EGFR). The nanocomposite system 5-FU/GO-PEG-GE11 was found to transfer 5-FU into EGFR-overexpressing HCT-116 cells effectively. The oxidation of glutathione in the tumor cells was found to be accelerated and then destroy the intracellular redox balance after irradiation. The 5-FU/GO-PEG-GE11 nanocomposites exhibited an enhanced synergistic anti-tumor efficacy both in vitro and in vivo. Tumor inhibition rate was 90 % in subcutaneous colorectal cancer (CRC) bearing mouse model. The GO-based nanocomposites serve as a versatile platform integrated of PTT and chemotherapy with EGFR-targeting ability, which hold great promise for CRC treatment.
资助项目	National Natural Science Foundation of China[31700706] ; National Natural Science Foundation of China[21877052] ; Natural Science Foundation of Jiangsu Province[BK20180030] ; Natural Science Foundation of Jiangsu Province[BK20171150] ; National Key R&D Program of China[2018YFA0901700] ; National First-class Discipline Program of Light Industry Technology and Engineering[LITE2018-14] ; Fundamental Research Funds for the Central Universities[JUSRP51712B] ; Max Planck Society International Partner Group Program ; "Six Talents Summit" funded project of Jiangsu Province[WSN-188]
WOS关键词	HYBRID HYDROGELS ; DRUG-DELIVERY ; COLON-CANCER ; 5-FLUOROURACIL ; CHEMOTHERAPY ; EGFR
WOS研究方向	Chemistry
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000521957200017
资助机构	National Natural Science Foundation of China ; Natural Science Foundation of Jiangsu Province ; National Key R&D Program of China ; National First-class Discipline Program of Light Industry Technology and Engineering ; Fundamental Research Funds for the Central Universities ; Max Planck Society International Partner Group Program ; "Six Talents Summit" funded project of Jiangsu Province
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/39854]
专题	中国科学院过程工程研究所
通讯作者	Hu, Jing; Mao, Yong; Hua, Dong
作者单位	1.Jiangnan Univ, Sch Biotechnol, Key Lab Carbohydrate Chem & Biotechnol, Minist Educ, Wuxi 214122, Jiangsu, Peoples R China 2.Jiangnan Univ, Dept Oncol, Affiliated Hosp, Wuxi 214062, Jiangsu, Peoples R China 3.Jiangnan Univ, Wuxi Sch Med, Wuxi 214122, Jiangsu, Peoples R China 4.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Qiu, Zhichao,Hu, Jing,Li, Ziwei,et al. Graphene oxide-based nanocomposite enabled highly efficient targeted synergistic therapy for colorectal cancer[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2020,593:8.
APA	Qiu, Zhichao.,Hu, Jing.,Li, Ziwei.,Yang, Xiaoxue.,Hu, Jun.,...&Yin, Jian.(2020).Graphene oxide-based nanocomposite enabled highly efficient targeted synergistic therapy for colorectal cancer.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,593,8.
MLA	Qiu, Zhichao,et al."Graphene oxide-based nanocomposite enabled highly efficient targeted synergistic therapy for colorectal cancer".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 593(2020):8.