Chemical constituents of Ruta graveolens L. and their melanogenic effects and action mechanism | |
Ainiwaer, P (Ainiwaer, Pazilaiti) 1 , 2; Nueraihemaiti, M (Nueraihemaiti, Mayire) 1 , 2; Li, ZP (Li, Zuopeng) 1; Zang, D (Zang, Deng) 1; Jiang, L (Jiang, Lan) 1Li, Y (Li, Ying) 2; Aisa, HA (Aisa, Haji Akber) 1 | |
刊名 | FITOTERAPIA |
2022 | |
卷号 | 156期号:1页码:1-8 |
关键词 | Ruta graveolens Vitiligo Melanogenesis MITF Akt/GSK-3 beta/beta-catenin |
ISSN号 | 0367-326X |
DOI | 10.1016/j.fitote.2021.105094 |
英文摘要 | Ruta graveolens L. has been widely used to treat various skin ailments, especially vitiligo. In this study, we isolated a new furanocoumarin named Rutagrarin (1) along with 14 known compounds (2-15) from the aerial parts of R. graveolens and elucidated their chemical structures via various spectroscopy. We found that compound 5 promoted melanogenesis and tyrosinase activity in B16 cells. Further investigation on underlying mechanisms revealed that compound 5 activated the transcription of microtia-related transcription factors and promoted the production of melanin in B16 cells via the Akt/GSK-3 beta/beta-catenin pathway. Therefore, we confirmed the traditional efficacy of R. graveolens and speculated that compound 5 could be used as a natural drug to treat vitiligo. |
WOS记录号 | WOS:000743466900004 |
内容类型 | 期刊论文 |
源URL | [http://ir.xjipc.cas.cn/handle/365002/8138] |
专题 | 新疆理化技术研究所_资源化学研究室 |
通讯作者 | Aisa, HA (Aisa, Haji Akber) 1 |
推荐引用方式 GB/T 7714 | Ainiwaer, P ,Nueraihemaiti, M ,Li, ZP ,et al. Chemical constituents of Ruta graveolens L. and their melanogenic effects and action mechanism[J]. FITOTERAPIA,2022,156(1):1-8. |
APA | Ainiwaer, P ,Nueraihemaiti, M ,Li, ZP ,Zang, D ,Jiang, L ,&Aisa, HA .(2022).Chemical constituents of Ruta graveolens L. and their melanogenic effects and action mechanism.FITOTERAPIA,156(1),1-8. |
MLA | Ainiwaer, P ,et al."Chemical constituents of Ruta graveolens L. and their melanogenic effects and action mechanism".FITOTERAPIA 156.1(2022):1-8. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论