I-2-induced cascade cyclization and dearomatization of indoles for the highly efficient synthesis of iodinated and vinylic spiroindolenines

doi:10.1039/d1gc02713a

	I-2-induced cascade cyclization and dearomatization of indoles for the highly efficient synthesis of iodinated and vinylic spiroindolenines
	Wei, Xiaohui 1,2; Liang, Xuewu 2; Li, Yazhou 2; Liu, Qi 2; Liu, Xuyi 2; Zhou, Yu 2; Liu, Hong 1,2
刊名	GREEN CHEMISTRY
	2021-11-16
卷号	23 期号:22 页码:9165-9171
ISSN号	1463-9262
DOI	10.1039/d1gc02713a
通讯作者	Zhou, Yu(zhouyu@simm.ac.cn) ; Liu, Hong(hliu@simm.ac.cn)
英文摘要	The spiroindolenine framework is a privileged heterocyclic motif and is widely present in numerous indole alkaloids. Herein, we develop a metal-free and environmentally friendly approach for the intramolecular cascade cyclization and dearomatization of indole derivatives to selectively afford iodinated and vinylic spiroindolenines by a substrate-controlled strategy. Simple operation, mild conditions, and high yield make this strategy a green and attractive pathway to construct functionalizable spiroindolenine scaffolds, which could be converted into diverse useful spiroindolenine derivatives.
资助项目	National Natural Science Foundation of China[21907102] ; National Natural Science Foundation of China[82130105] ; National Natural Science Foundation of China[82121005]
WOS关键词	ASYMMETRIC ALLYLIC DEAROMATIZATION ; MOLECULAR-IODINE ; ELECTROPHILIC CYCLIZATION ; GARDNERIA ALKALOIDS ; GOLD ; IODOCYCLIZATION ; NANOPARTICLES ; ALKYLATION
WOS研究方向	Chemistry ; Science & Technology - Other Topics
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000714407400001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/298790]
专题	中国科学院上海药物研究所
通讯作者	Zhou, Yu; Liu, Hong
作者单位	1.China Pharmaceut Univ, 639 Longmian Ave, Nanjing 211198, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Wei, Xiaohui,Liang, Xuewu,Li, Yazhou,et al. I-2-induced cascade cyclization and dearomatization of indoles for the highly efficient synthesis of iodinated and vinylic spiroindolenines[J]. GREEN CHEMISTRY,2021,23(22):9165-9171.
APA	Wei, Xiaohui.,Liang, Xuewu.,Li, Yazhou.,Liu, Qi.,Liu, Xuyi.,...&Liu, Hong.(2021).I-2-induced cascade cyclization and dearomatization of indoles for the highly efficient synthesis of iodinated and vinylic spiroindolenines.GREEN CHEMISTRY,23(22),9165-9171.
MLA	Wei, Xiaohui,et al."I-2-induced cascade cyclization and dearomatization of indoles for the highly efficient synthesis of iodinated and vinylic spiroindolenines".GREEN CHEMISTRY 23.22(2021):9165-9171.