Photoactivatable nanogenerators of reactive species for cancer therapy

doi:10.1016/j.bioactmat.2021.04.030

	Photoactivatable nanogenerators of reactive species for cancer therapy
	Zheng, Xiaohua 1; Jin, Yilan 1,2,3; Liu, Xiao 1; Liu, Tianqing 4; Wang, Weiqi 1,2,3; Yu, Haijun 2,3
刊名	BIOACTIVE MATERIALS
	2021-12-01
卷号	6 期号:12 页码:4301-4318
关键词	Reactive oxygen species Reactive nitrogen species Alkyl radicals Carbon monoxide Phototherapy
DOI	10.1016/j.bioactmat.2021.04.030
通讯作者	Wang, Weiqi(wwq1990@ntu.edu.cn) ; Yu, Haijun(hjyu@simm.ac.cn)
英文摘要	In recent years, reactive species-based cancer therapies have attracted tremendous attention due to their simplicity, controllability, and effectiveness. Herein, we overviewed the state-of-art advance for photo-controlled generation of highly reactive radical species with nanomaterials for cancer therapy. First, we summarized the most widely explored reactive species, such as singlet oxygen, superoxide radical anion (O-2(center dot-)), nitric oxide ((NO)-N-center dot), carbon monoxide, alkyl radicals, and their corresponding secondary reactive species generated by interaction with other biological molecules. Then, we discussed the generating mechanisms of these highly reactive species stimulated by light irradiation, followed by their anticancer effect, and the synergetic principles with other therapeutic modalities. This review might unveil the advantages of reactive species-based therapeutic methodology and encourage the pre-clinical exploration of reactive species-mediated cancer treatments.
资助项目	National Natural Science Foundation of China[31900990] ; National Natural Science Foundation of China[51873228] ; International Cooperation Project of Science and Technology Commission of Shanghai Municipality[20430711800] ; Scientific Research Foundation of Nantong University[135420623085]
WOS关键词	GENERATING NADPH OXIDASES ; NITRIC-OXIDE DONORS ; PHOTODYNAMIC THERAPY ; FREE-RADICALS ; OXIDATIVE STRESS ; IN-VITRO ; CONTROLLABLE RELEASE ; SONODYNAMIC THERAPY ; OXYGEN ; ROS
WOS研究方向	Engineering ; Materials Science
语种	英语
出版者	KEAI PUBLISHING LTD
WOS记录号	WOS:000709332400003
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/298671]
专题	中国科学院上海药物研究所
通讯作者	Wang, Weiqi; Yu, Haijun
作者单位	1.Nantong Univ, Sch Pharm, Nantong 226001, Jiangsu, Peoples R China 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 4.Western Sydney Univ, NICM Hlth Res Inst, Westmead, NSW, Australia
推荐引用方式 GB/T 7714	Zheng, Xiaohua,Jin, Yilan,Liu, Xiao,et al. Photoactivatable nanogenerators of reactive species for cancer therapy[J]. BIOACTIVE MATERIALS,2021,6(12):4301-4318.
APA	Zheng, Xiaohua,Jin, Yilan,Liu, Xiao,Liu, Tianqing,Wang, Weiqi,&Yu, Haijun.(2021).Photoactivatable nanogenerators of reactive species for cancer therapy.BIOACTIVE MATERIALS,6(12),4301-4318.
MLA	Zheng, Xiaohua,et al."Photoactivatable nanogenerators of reactive species for cancer therapy".BIOACTIVE MATERIALS 6.12(2021):4301-4318.