| Acmoxanthones A-E, New Lavandulated Xanthones from Hypericum acmosepalum N. Robson | |
| Wang, Ai-Zhu1,2; Fang, Qiang-Qiang2; Feng, Tong-Tong1; Wei, Ren-Jie2; Jiang, Kun2; Lu, Qun1; Tan, Chang-Heng2 | |
| 刊名 | FITOTERAPIA
 |
| 2021-10-01 | |
| 卷号 | 154页码:5 |
| 关键词 | Hypericum acmosepalum Clusiaceae Xanthones Antioxidant Cytotoxicity |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2021.104923 |
| 通讯作者 | Lu, Qun(luqun1125@126.com) ; Tan, Chang-Heng(chtan@simm.ac.cn) |
| 英文摘要 | Acmoxanthones A-E (1-5), five new lavandulylated xanthones, were isolated from the aerial parts of Hypericum acmosepalum, together with four known xanthones. Their structures with absolute configurations were elucidated on the basis of analysis of MS, NMR and chiroptical properties. A bioassay against high glucose-induced damage on human umbilical vein endothelial cells (HUVECs) showed ananixanthone (6) and osajaxanthone (7) had potential antioxidative damage activity with EC50 values of 10.5 mu g/mL and 7.6 mu g/mL, respectively, while 3-hydroxy-2,4-dimethoxyxanthone (8) exhibited cytotoxic effect on the damaged cells with IC50 values of 7.1 mu g/mL. |
| 资助项目 | National Science & Technology Major Project Key New Drug Creation and Manufacturing Program of the National Health Commission of China[2019ZX09201001] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program of the National Health Commission of China[2018ZX09735001-002-005] |
| WOS关键词 | ROOTS |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:000705651100001 |
| 内容类型 | 期刊论文 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/298418]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Lu, Qun; Tan, Chang-Heng |
| 作者单位 | 1.Southwest Jiaotong Univ, Sch Life Sci & Engn, Chengdu 610000, Peoples R China 2.Chinese Acad Sci, Nat Prod Res Ctr, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Ai-Zhu,Fang, Qiang-Qiang,Feng, Tong-Tong,et al. Acmoxanthones A-E, New Lavandulated Xanthones from Hypericum acmosepalum N. Robson[J]. FITOTERAPIA,2021,154:5. |
| APA | Wang, Ai-Zhu.,Fang, Qiang-Qiang.,Feng, Tong-Tong.,Wei, Ren-Jie.,Jiang, Kun.,...&Tan, Chang-Heng.(2021).Acmoxanthones A-E, New Lavandulated Xanthones from Hypericum acmosepalum N. Robson.FITOTERAPIA,154,5. |
| MLA | Wang, Ai-Zhu,et al."Acmoxanthones A-E, New Lavandulated Xanthones from Hypericum acmosepalum N. Robson".FITOTERAPIA 154(2021):5. |
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