Two New Phenol Derivatives from the Cold Seep-Derived Fungus Aspergillus insuetus SD-512

doi:10.1002/cbdv.202100512

CORC > 海洋研究所 > 中国科学院海洋研究所 > 实验海洋生物学重点实验室

	Two New Phenol Derivatives from the Cold Seep-Derived Fungus Aspergillus insuetus SD-512
	Chi, Lu-Ping 1,2,4; Li, Xiao-Ming 2,4; Wan, Yu-Peng 2; Li, Yan-He 1,2,4; Li, Xin 2,4; Wang, Bin-Gui 2,3,4
刊名	CHEMISTRY & BIODIVERSITY
	2021-09-16
页码	6
关键词	Aspergillus insuetus cold seep-derived fungus marine natural products antibacterial activity
ISSN号	1612-1872
DOI	10.1002/cbdv.202100512
通讯作者	Li, Xin(lixin@qdio.ac.cn) ; Wang, Bin-Gui(wangbg@nns.qdio.ac.cn)
英文摘要	Two new phenol derivatives, namely insphenol A (1) and acetylpeniciphenol (2), along with seven known analogs (3-9), were isolated from the deep-sea cold seep-derived fungus, Aspergillus insuetus SD-512. The structures of 1 and 2 were established by extensive interpretation of NMR and mass spectroscopic data. The absolute configuration of 1 was determined by the combination of coupling constant analysis and acid hydrolysis. Among the isolated compounds, insphenol A (1) represents the first example of isopentenyl phenol derivative with a unique 1-glycosylation from the species Aspergillus insuetus. The isolated new compounds were evaluated for antibacterial activities against six human or aquatic pathogens, while compound 2 exhibited inhibitory effect against Edwardsiella tarda, Vibrio alginolyticus, and V. vulnificus, with MIC values of 4, 8, and 8 mu g/mL, respectively.
资助项目	National Key R&D Program of China[2018YFC0310800] ; National Natural Science Foundation of China[42076090] ; National Natural Science Foundation of China[U2006203] ; Shandong Provincial Natural Science Foundation[ZR2019ZD18] ; Basic Applied Research program of Qingdao[19-6-2-40-cg] ; Senior User Project of RV KEXUE[KEXUE2020GZ02] ; Center for Ocean Mega-Science, Chinese Academy of Sciences ; Taishan Scholar Project from Shandong Province[ts201511060]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000696224300001
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/176388]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Li, Xin; Wang, Bin-Gui
作者单位	1.Univ Chinese Acad Sci, Yuquan Rd 19 A, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Megasci, Nanhai Rd 7, Qingdao 266071, Peoples R China 4.Qingdao Natl Lab Marine Sci & Tech, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China
推荐引用方式 GB/T 7714	Chi, Lu-Ping,Li, Xiao-Ming,Wan, Yu-Peng,et al. Two New Phenol Derivatives from the Cold Seep-Derived Fungus Aspergillus insuetus SD-512[J]. CHEMISTRY & BIODIVERSITY,2021:6.
APA	Chi, Lu-Ping,Li, Xiao-Ming,Wan, Yu-Peng,Li, Yan-He,Li, Xin,&Wang, Bin-Gui.(2021).Two New Phenol Derivatives from the Cold Seep-Derived Fungus Aspergillus insuetus SD-512.CHEMISTRY & BIODIVERSITY,6.
MLA	Chi, Lu-Ping,et al."Two New Phenol Derivatives from the Cold Seep-Derived Fungus Aspergillus insuetus SD-512".CHEMISTRY & BIODIVERSITY (2021):6.