Impaired robust interhemispheric function integration of depressive brain from REST-meta-MDD database in China. | |
Deng, Ke; Yue, Ji-Hui; Xu, Jian; Ma, Ping-Ping; Chen, Xiao; Li, Le; Bai, Tong-Jian; Bo, Qi-Jing; Cao, Jun; Chen, Guan-Mao | |
刊名 | Bipolar Disorders |
2021 | |
ISSN号 | 1399-5618 |
DOI | 10.1111/bdi.13139 |
产权排序 | 8 |
文献子类 | 实证研究 |
英文摘要 | BACKGROUND: Recently, functional homotopy (FH) architecture, defined as robust functional connectivity (FC) between homotopic regions, has been frequently reported to be altered in MDD patients (MDDs) but with divergent locations. METHODS: In this study, we obtained resting-state functional magnetic resonance imaging (R-fMRI) data from 1004 MDDs (mean age, 33.88 years; age range, 18-60 years) and 898 matched healthy controls (HCs) from an aggregated dataset from 20 centers in China. We focused on interhemispheric function integration in MDDs and its correlation with clinical characteristics using voxel-mirrored homotopic connectivity (VMHC) devised to inquire about FH patterns. RESULTS: As compared with HCs, MDDs showed decreased VMHC in visual, motor, somatosensory, limbic, angular gyrus, and cerebellum, particularly in posterior cingulate gyrus/precuneus (PCC/PCu) (false discovery rate [FDR] q < .002, z =-7.07). Further analysis observed that the reduction in SMG and insula was more prominent with age, of which SMG reflected such age-related change in males instead of females. Besides, the reduction of MTG was found to bea male-special abnormal pattern in MDDs. VMHC alterations were markedly related to episode type and illness severity. The higher Hamilton Depression Rating Scale score, the more apparent VMHC reduction in the primary visual cortex. First-episode MDDs revealed stronger VMHC reduction in PCu relative to recurrent MDDs. |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/40740] |
专题 | 心理研究所_中国科学院行为科学重点实验室 |
作者单位 | 1.Department of Psychiatry, Shanghai Jiao Tong University School of Medicine, Shanghai, 200240, China. 2.Mental Health Center, West China Hospital, Sichuan University Chengdu, Sichuan, 610041, China. 3.Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, 210096, China. 4.Psychoradiology Research Unit of Chinese Academy of Medical Sciences, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041, China. 5.Department of Radiology, Huaxi MR Research Center, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041, China. 6.Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. 7.Beijing Anding Hospital, Capital Medical University, Beijing, 100054, China. 8.Anhui Medical University, Hefei, Anhui, 230022, China. 9.Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, 100101, China. 10.Department of Psychology, University of Chinese Academy of Sciences, Beijing, 100049, China. |
推荐引用方式 GB/T 7714 | Deng, Ke,Yue, Ji-Hui,Xu, Jian,et al. Impaired robust interhemispheric function integration of depressive brain from REST-meta-MDD database in China.[J]. Bipolar Disorders,2021. |
APA | Deng, Ke.,Yue, Ji-Hui.,Xu, Jian.,Ma, Ping-Ping.,Chen, Xiao.,...&Cheng, Yu-Qi.(2021).Impaired robust interhemispheric function integration of depressive brain from REST-meta-MDD database in China..Bipolar Disorders. |
MLA | Deng, Ke,et al."Impaired robust interhemispheric function integration of depressive brain from REST-meta-MDD database in China.".Bipolar Disorders (2021). |
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