The role of hippocampus in memory reactivation: an implication for a therapeutic target against opioid use disorder

doi:10.1007/s40429-022-00407-w

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	The role of hippocampus in memory reactivation: an implication for a therapeutic target against opioid use disorder
	Dai, Zhong-hua 1,3; Xu, Xing 1,3; Chen, Wei-qi 1,2,3; Nie, Li-na 1,3; Liu, Ying 1,3; Sui, Nan 1,3; Liang, Jing 1,2,3
刊名	CURRENT ADDICTION REPORTS
	2022-02-19
页码	13
关键词	opioid withdrawal memory reactivation extinction hippocampus noradrenergic signaling
DOI	10.1007/s40429-022-00407-w
通讯作者	Liang, Jing(liangj@psych.ac.cn)
英文摘要	Purpose of the review The abuse of opioids induces many terrible problems in human health and social stability. For opioid-dependent individuals, withdrawal memory can be reactivated by context, which is then associated with extremely unpleasant physical and emotional feelings during opioid withdrawal. The reactivation of withdrawal memory is considered one of the most important reasons for opioid relapse, and it also allows for memory modulation based on the reconsolidation phenomenon. However, studies exploring withdrawal memory modulation during the reconsolidation window are lacking. By summarizing the previous findings about the reactivation of negative emotional memories, we are going to suggest potential neural regions and systems for modulating opioid withdrawal memory. Recent findings Here, we first present the role of memory reactivation in its modification, discuss how the hippocampus participates in memory reactivation, and discuss the importance of noradrenergic signaling in the hippocampus for memory reactivation. Then, we review the engagement of other limbic regions receiving noradrenergic signaling in memory reactivation. We suggest that noradrenergic signaling targeting hippocampus neurons might play a potential role in strengthening the disruptive effect of withdrawal memory extinction by facilitating the degree of memory reactivation. This review will contribute to a better understanding of the mechanisms underlying reactivation-dependent memory malleability and will provide new therapeutic avenues for treating opioid use disorders.
收录类别	SCI
资助项目	National Natural Science Foundation of China[32071028] ; Natural Science Foundation of Beijing Municipality[5202023] ; CAS-VPST Silk Road Science Fund[GJHZ202129] ; CAS Key Laboratory of Mental Health, Institute of Psychology
WOS关键词	CONDITIONED PLACE PREFERENCE ; BETA-ADRENERGIC-RECEPTORS ; RETRIEVAL-EXTINCTION PROCEDURE ; INHIBITORY AVOIDANCE MEMORY ; D2-LIKE DOPAMINE-RECEPTORS ; VENTRAL TEGMENTAL AREA ; LOCUS-COERULEUS ; OPIATE WITHDRAWAL ; DENTATE GYRUS ; CA1 REGION
WOS研究方向	Substance Abuse ; Psychiatry
语种	英语
出版者	SPRINGERNATURE
WOS记录号	WOS:000758307800001
资助机构	National Natural Science Foundation of China ; Natural Science Foundation of Beijing Municipality ; CAS-VPST Silk Road Science Fund ; CAS Key Laboratory of Mental Health, Institute of Psychology
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/42056]
专题	心理研究所_中国科学院心理健康重点实验室
通讯作者	Liang, Jing
作者单位	1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Sino Danish Coll, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Dai, Zhong-hua,Xu, Xing,Chen, Wei-qi,et al. The role of hippocampus in memory reactivation: an implication for a therapeutic target against opioid use disorder[J]. CURRENT ADDICTION REPORTS,2022:13.
APA	Dai, Zhong-hua.,Xu, Xing.,Chen, Wei-qi.,Nie, Li-na.,Liu, Ying.,...&Liang, Jing.(2022).The role of hippocampus in memory reactivation: an implication for a therapeutic target against opioid use disorder.CURRENT ADDICTION REPORTS,13.
MLA	Dai, Zhong-hua,et al."The role of hippocampus in memory reactivation: an implication for a therapeutic target against opioid use disorder".CURRENT ADDICTION REPORTS (2022):13.