Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups | |
Clausen, Ashley N.48,49,50; Fercho, Kelene A.8,39,53,57; Monsour, Molly49; Disner, Seth22,43,53; Salminen, Lauren30; Haswell, Courtney C.48,49; Rubright, Emily Clarke48,49; Watts, Amanda A.48,49; Buckley, M. Nicole48,49; Maron-Katz, Adi66 | |
刊名 | BRAIN AND BEHAVIOR |
2021-12-14 | |
通讯作者邮箱 | ashley.n.clausen@gmail.com, ashley.clausen@sclhealth.org |
页码 | 14 |
关键词 | aging machine learning mega-analysis neuroimaging posttraumatic stress disorder trauma |
ISSN号 | 2162-3279 |
DOI | 10.1002/brb3.2413 |
产权排序 | 1 |
文献子类 | 实证研究 |
英文摘要 | Background Posttraumatic stress disorder (PTSD) is associated with markers of accelerated aging. Estimates of brain age, compared to chronological age, may clarify the effects of PTSD on the brain and may inform treatment approaches targeting the neurobiology of aging in the context of PTSD. Method Adult subjects (N = 2229; 56.2% male) aged 18-69 years (mean = 35.6, SD = 11.0) from 21 ENIGMA-PGC PTSD sites underwent T1-weighted brain structural magnetic resonance imaging, and PTSD assessment (PTSD+, n = 884). Previously trained voxel-wise (brainageR) and region-of-interest (BARACUS and PHOTON) machine learning pipelines were compared in a subset of control subjects (n = 386). Linear mixed effects models were conducted in the full sample (those with and without PTSD) to examine the effect of PTSD on brain predicted age difference (brain PAD; brain age - chronological age) controlling for chronological age, sex, and scan site. Results BrainageR most accurately predicted brain age in a subset (n = 386) of controls (brainageR: ICC = 0.71, R = 0.72, MAE = 5.68; PHOTON: ICC = 0.61, R = 0.62, MAE = 6.37; BARACUS: ICC = 0.47, R = 0.64, MAE = 8.80). Using brainageR, a three-way interaction revealed that young males with PTSD exhibited higher brain PAD relative to male controls in young and old age groups; old males with PTSD exhibited lower brain PAD compared to male controls of all ages. Discussion Differential impact of PTSD on brain PAD in younger versus older males may indicate a critical window when PTSD impacts brain aging, followed by age-related brain changes that are consonant with individuals without PTSD. Future longitudinal research is warranted to understand how PTSD impacts brain aging across the lifespan. |
收录类别 | SCI |
资助项目 | Academic Medical Center Research Council ; Center for Brain and Behavior Research Pilot Grant ; National Center for Advancing Translational Sciences ; Department of Veterans Affairs RRD ; Canadian Institute for Military and Veteran Health Research ; National Center for Research Resources[CX001600] ; National Institutes of Health[K01MH122774] ; National Institutes of Health[R01 MH106574] ; Brain and Behavior Research Foundation[07040] ; VA Career Development Award ; National Institute on Alcohol Abuse and Alcoholism ; South Dakota Governor's Research Center Grant ; National Institute of Mental Health[F31MH113271] ; National Institute of Mental Health[K23MH112873] ; National Institute of Mental Health[R01-MH043454] ; National Institute of Mental Health[T32MH018931] ; National Institute of Mental Health[T32MH13043] ; Trauma Scholars Fund ; NIH from the Big Data to Knowledge (BD2K) program[U54 EB020403] ; German Research Society ; U.S. Department of Defense[W81XWH-10-1-0925] ; U.S. Department of Defense[W81XWH082-0159] ; NHMRC Career Development Fellowship ; Deutsche Forschungsgemeinschaft[DA1222/4-1] ; Deutsche Forschungsgemeinschaft[SFB/TRR 58] ; Deutsche Forschungsgemeinschaft[WA1539/8-2] ; U.S. Department of Veterans Affairs ; Barlow Family Fund ; Veterans Affairs Merit Review Program ; Institute of Neurosciences, Mental Health and Addiction ; German Federal Ministry of Education and Research ; Congressionally Directed Medical Research Programs[W81XWH08-2-0038] ; Kasparian Fund ; Netherlands organization for Health Research and Development ; MRC/UKRI Innovation Fellowship ; VISN6 MIRECC ; Bijzonder Onderzoeksfonds UGent ; Anonymous Women's Health Fund |
WOS关键词 | CHILDHOOD TRAUMA ; DEPRESSION ; ANXIETY ; SCHIZOPHRENIA ; PREDICTION ; MATURITY ; VALIDITY ; VOLUME |
WOS研究方向 | Behavioral Sciences ; Neurosciences & Neurology |
语种 | 英语 |
出版者 | WILEY |
WOS记录号 | WOS:000730010700001 |
资助机构 | Academic Medical Center Research Council ; Center for Brain and Behavior Research Pilot Grant ; National Center for Advancing Translational Sciences ; Department of Veterans Affairs RRD ; Canadian Institute for Military and Veteran Health Research ; National Center for Research Resources ; National Institutes of Health ; Brain and Behavior Research Foundation ; VA Career Development Award ; National Institute on Alcohol Abuse and Alcoholism ; South Dakota Governor's Research Center Grant ; National Institute of Mental Health ; Trauma Scholars Fund ; NIH from the Big Data to Knowledge (BD2K) program ; German Research Society ; U.S. Department of Defense ; NHMRC Career Development Fellowship ; Deutsche Forschungsgemeinschaft ; U.S. Department of Veterans Affairs ; Barlow Family Fund ; Veterans Affairs Merit Review Program ; Institute of Neurosciences, Mental Health and Addiction ; German Federal Ministry of Education and Research ; Congressionally Directed Medical Research Programs ; Kasparian Fund ; Netherlands organization for Health Research and Development ; MRC/UKRI Innovation Fellowship ; VISN6 MIRECC ; Bijzonder Onderzoeksfonds UGent ; Anonymous Women's Health Fund |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/41400] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Clausen, Ashley N. |
作者单位 | 1.Univ Munster, Inst Med Psychol & Syst Neurosci, Munster, Germany 2.Harvard Univ, McLean Hosp, Inst Technol Psychiat, Belmont, MA 02178 USA 3.Lawson Hlth Res Inst, Imaging Div, London, ON, Canada 4.Harvard Med Sch, Boston, MA 02115 USA 5.Radboud Univ Nijmegen, Ctr Cognit Neuroimaging, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands 6.McLean Hosp, Div Womens Mental Hlth, 115 Mill St, Belmont, MA 02178 USA 7.McLean Hosp, Div Depress & Anxiety Disorders, 115 Mill St, Belmont, MA 02178 USA 8.Univ South Dakota, Sanford Sch Med, Div Basic Biomed Sci, Vermillion, SD USA 9.Univ Iowa, Dept Biomed Engn, Iowa City, IA 52242 USA 10.Univ Iowa, Dept Psychiat, Iowa City, IA 52242 USA |
推荐引用方式 GB/T 7714 | Clausen, Ashley N.,Fercho, Kelene A.,Monsour, Molly,et al. Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups[J]. BRAIN AND BEHAVIOR,2021:14. |
APA | Clausen, Ashley N..,Fercho, Kelene A..,Monsour, Molly.,Disner, Seth.,Salminen, Lauren.,...&Morey, Rajendra A..(2021).Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups.BRAIN AND BEHAVIOR,14. |
MLA | Clausen, Ashley N.,et al."Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups".BRAIN AND BEHAVIOR (2021):14. |
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