Advances in Mitochondrial Ultrastructure and Its Regulatory Mechanism

doi:10.16476/j.pibb.2019.0142

	Advances in Mitochondrial Ultrastructure and Its Regulatory Mechanism
	Huang Guo-Min 1,2,3,4; Wang Yu-Pei 5; Sun Chao 1,2,3,4; Zhang Xue-Tian 1,2,3,4; Zhang Hong 1,2,3,4
刊名	PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
	2019-12-01
卷号	46 期号:12 页码:1141-1149
关键词	mitochondria ultrastructure Crista junction MICOS F1F0-ATP synthase
ISSN号	1000-3282
DOI	10.16476/j.pibb.2019.0142
通讯作者	Zhang Hong(zhangh@impcas.ac.cn)
英文摘要	Mitochondrial ultrastructure is a fine structure observed by electron microscope, which can be changed according to different energy requirements and physiological environment, and plays a key role in regulating mitochondrial function. The structure of mitochondrial cristae is an important mitochondrial ultrastructure, which affects many mitochondrial diseases. Therefore, studying the function and understanding the regulation mechanism of mitochondrial ultrastructure have important guiding significance for studying mitochondrial diseases and looking for therapeutic targets. This paper introduces the main regulating mechanism of mitochondrial cristae in detail, and focuses on the research progress in the composition of mitochondrial ultrastructure, the effect of mitochondrial ultrastructure on mitochondrial function, and the relationship between mitochondrial ultrastructure and mitochondrial disease, in order to provide theoretical reference for developing more effective mitochondrial disease treatment.
资助项目	Ministry of Science and Technology National Key RD Project[SQ2018YFE020524]
WOS关键词	DOMINANT OPTIC ATROPHY ; CONTACT SITE ; COMPLEX I ; MEMBRANE ARCHITECTURE ; PARKINSONS-DISEASE ; ORGANIZING SYSTEM ; CALCIUM UNIPORTER ; CA2+ UNIPORTER ; BARTH SYNDROME ; ATP SYNTHASE
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
语种	英语
出版者	CHINESE ACAD SCIENCES, INST BIOPHYSICS
WOS记录号	WOS:000504952900001
资助机构	Ministry of Science and Technology National Key RD Project
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/141348]
专题	中国科学院近代物理研究所
通讯作者	Zhang Hong
作者单位	1.Univ Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Gansu, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Gansu, Peoples R China 4.Key Lab Heavy Ion Radiat Med Gansu Prov, Lanzhou 730000, Gansu, Peoples R China 5.Gansu Prov Maternal & Child Hlth Care Ctr, Lanzhou 730000, Gansu, Peoples R China
推荐引用方式 GB/T 7714	Huang Guo-Min,Wang Yu-Pei,Sun Chao,et al. Advances in Mitochondrial Ultrastructure and Its Regulatory Mechanism[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2019,46(12):1141-1149.
APA	Huang Guo-Min,Wang Yu-Pei,Sun Chao,Zhang Xue-Tian,&Zhang Hong.(2019).Advances in Mitochondrial Ultrastructure and Its Regulatory Mechanism.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,46(12),1141-1149.
MLA	Huang Guo-Min,et al."Advances in Mitochondrial Ultrastructure and Its Regulatory Mechanism".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 46.12(2019):1141-1149.