Nanodosimetric quantities and RBE of a clinically relevant carbon-ion beam

doi:10.1002/mp.13914

	Nanodosimetric quantities and RBE of a clinically relevant carbon-ion beam
	Dai, Tianyuan ; Li, Qiang 1; Liu, Xinguo ; Dai, Zhongying ; He, Pengbo ; Ma, Yuanyuan ; Shen, Guosheng ; Chen, Weiqiang ; Zhang, Hui ; Meng, Qianqian
刊名	MEDICAL PHYSICS
	2019-11-28
页码	9
关键词	carbon-ion therapy Monte Carlo simulations nanodosimetry track structure
ISSN号	0094-2405
DOI	10.1002/mp.13914
通讯作者	Li, Qiang(liqiang@impcas.ac.cn)
英文摘要	Purpose Although carbon-ion therapy is becoming increasingly attractive to the treatment of tumors, details about the ionization pattern formed by therapeutic carbon-ion beam in tissue have not been fully investigated. In this work, systematic calculations for the nanodosimetric quantities and relative biological effectiveness (RBE) of a clinically relevant carbon-ion beam were studied for the first time. Methods The method combining both track structure and condensed history Monte Carlo (MC) simulations was adopted to calculate the nanodosimetric quantities. Fragments and energy spectra at different positions of the radiation field of a clinically relevant carbon-ion pencil beam were generated by means of MC simulations in water. Nanodosimetric quantities such as mean ionization cluster size (M1), the first moment of conditional cluster size (M1C2), cumulative probability (F2), and conditional cumulative probability (F3C2) at these positions were then acquired based on the spectra and the pre-calculated nanodosimetric database created by track structure MC simulations. What's more, a novel approach to calculate RBE based on the said nanodosimetric quantities was introduced. The RBE calculations were then conducted for the carbon-ion beam at different water-equivalent depths. Results Lateral distributions at various water-equivalent depths of both the nanodosimetric quantities and RBE values were obtained. The values of M1, M1C2, F2, and F3C2 were 1.49, 2.67, 0.30, and 0.38 at the plateau at the beam central axis and maximized at 2.79, 5.69, 0.47, and 0.68 at the depths around the Bragg peak, respectively. At a given depth, M1 and F2 decreased laterally with increasing the distance to the beam central axis while M1C2 and F3C2 remained nearly unchanged at first and then decreased except for M1C2 at the rising edge of the Bragg peak. The calculated RBE values were 1.07 at the plateau and 3.13 around the Bragg peak. Good agreement between the calculated RBE values and experimental data was obtained. Conclusions Different nanodosimetric quantities feature the track structure of therapeutic carbon-ion beam in different manners. Detailed ionization patterns generated by carbon-ion beam could be characterized by nanodosimetric quantities. Moreover the combined method adopted in this work to calculate nanodosimetric quantities is not only valid but also convenient. Nanodosimetric quantities are significantly helpful for the RBE calculations in carbon-ion therapy.
资助项目	National Key Research and Development Program of China[2018YFC0115700] ; National Key Research and Development Program of China[2018YFC0115702] ; National Natural Science Foundation of China[61631001] ; National Natural Science Foundation of China[U1532264] ; National Natural Science Foundation of China[11875299] ; National Natural Science Foundation of China[11705247] ; National Natural Science Foundation of China[11505249] ; National Natural Science Foundation of China[11475231]
WOS关键词	MONTE-CARLO PLATFORM ; IONIZATION CLUSTERS ; LIQUID WATER ; PROTON ; ENERGY ; RADIATION ; THERAPY ; MODELS ; GATE ; RADIOBIOLOGY
WOS研究方向	Radiology, Nuclear Medicine & Medical Imaging
语种	英语
出版者	WILEY
WOS记录号	WOS:000499006300001
资助机构	National Key Research and Development Program of China ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/141230]
专题	中国科学院近代物理研究所
通讯作者	Li, Qiang
作者单位	1.Chinese Acad Sci, Inst Modern Phys, Lanzhou 73000, Gansu, Peoples R China 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Gansu, Peoples R China 3.Key Lab Basic Res Heavy Ion Radiat Applicat Med G, Lanzhou 730000, Gansu, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Dai, Tianyuan,Li, Qiang,Liu, Xinguo,et al. Nanodosimetric quantities and RBE of a clinically relevant carbon-ion beam[J]. MEDICAL PHYSICS,2019:9.
APA	Dai, Tianyuan.,Li, Qiang.,Liu, Xinguo.,Dai, Zhongying.,He, Pengbo.,...&Zhang, Xiaofang.(2019).Nanodosimetric quantities and RBE of a clinically relevant carbon-ion beam.MEDICAL PHYSICS,9.
MLA	Dai, Tianyuan,et al."Nanodosimetric quantities and RBE of a clinically relevant carbon-ion beam".MEDICAL PHYSICS (2019):9.