Multifunctional Nanoparticles in Precise Cancer Treatment: Considerations in Design and Functionalization of Nanocarriers

doi:10.2174/1568026620666200825170030

	Multifunctional Nanoparticles in Precise Cancer Treatment: Considerations in Design and Functionalization of Nanocarriers
	Lu, Lina 3,4; Kang, Shuhe 3,4; Sun, Chao 2; Sun, Chufeng 3,4; Guo, Zhong 1; Li, Jia 3,4; Zhang, Taofeng 5; Luo, Xingping 3,4; Liu, Bin 5
刊名	CURRENT TOPICS IN MEDICINAL CHEMISTRY
	2020
卷号	20 期号:27 页码:2427-2441
关键词	Nanoparticles Targeted cancer treatment Physiochemical characteristics Targeting strategies Clinical applications Toxicity
ISSN号	1568-0266
DOI	10.2174/1568026620666200825170030
通讯作者	Liu, Bin(liubin_edu@yeah.net)
英文摘要	Nanotechnology has revolutionized cancer treatment in both diagnosis and therapy. Since the initial application of nanoparticles (NPs) in cancer treatment, the main objective of nanotechnology was developing effective nanosystems with high selectivity and specificity for cancer treatment and diagnosis. To achieve this, different encapsulation and conjugation strategies along with surface functionalization techniques have been developed to synthesize anticancer drugs loaded NPs with effective targeting to specific tumor cells. The unique physicochemical attributes of NPs make them promising candidates for targeted drug delivery, localized therapies, sensing, and targeting at cellular levels. However, a nanosystem for localized and targeted cancer managements should overcome several biological barriers and biomedical challenges such as endothelial barriers, blood brain barrier, reticuloendothelial system, selective targeting, biocompatibility, acute/chronic toxicity, tumor-targeting efficacy. The NPs for in vivo applications encounter barriers at system, organ, and the cellular level. To overcome these barriers, different strategies during the synthesis and functionalization of NPs should be adapted. Pharmacoldnetics and cellular uptake of NPs are largely associated with physicochemical attributes of NPs, morphology, hydrodynamic size, charge, and other surface properties. These properties can be adjusted during different phases of synthesis and functionalization of the NPs. This study reviews the advances in targeted cancer treatment and the parameters influencing the efficacies of NPs as therapeutics. Different strategies for overcoming the biological barriers at cellular, organ and system levels and biomedical challenges are discussed. Moreover, the applications of NPs in preclinical and clinical practice are reviewed.
资助项目	Fundamental Research Funds for the Central Universities[31920190013] ; Fundamental Research Funds for the Central Universities[31920190018] ; Fundamental Research Funds for the Central Universities[31920180020] ; Northwest Minzu University's Double First-class and Characteristic Development Guide Special Funds Chemistry Key Disciplines in Gansu Province[11080316] ; National Natural Science Foundation of China[81560508] ; National Natural Science Foundation of China[11775280] ; National Natural Science Foundation of China[81970976]
WOS关键词	LONG-CIRCULATING NANOPARTICLES ; ALBUMIN-BOUND PACLITAXEL ; IN-VIVO BIODISTRIBUTION ; DRUG-DELIVERY SYSTEMS ; B-CELL LYMPHOMA ; MAGNETIC NANOPARTICLES ; BLOOD CLEARANCE ; QUANTUM DOTS ; PHASE-I ; SUPERPARAMAGNETIC NANOPARTICLES
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	BENTHAM SCIENCE PUBL LTD
WOS记录号	WOS:000590232100002
资助机构	Fundamental Research Funds for the Central Universities ; Northwest Minzu University's Double First-class and Characteristic Development Guide Special Funds Chemistry Key Disciplines in Gansu Province ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/138169]
专题	中国科学院近代物理研究所
通讯作者	Liu, Bin
作者单位	1.Northwest Minzu Univ, Med Coll, Lanzhou 730000, Gansu, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China 3.Northwest Minzu Univ, Sch Chem Engn, Lanzhou, Gansu, Peoples R China 4.Key Lab Util Environm Friendly Composite Mat & Bi, Lanzhou 730124, Peoples R China 5.Lanzhou Univ, Sch Nucl Sci & Technol, Lanzhou, Gansu, Peoples R China
推荐引用方式 GB/T 7714	Lu, Lina,Kang, Shuhe,Sun, Chao,et al. Multifunctional Nanoparticles in Precise Cancer Treatment: Considerations in Design and Functionalization of Nanocarriers[J]. CURRENT TOPICS IN MEDICINAL CHEMISTRY,2020,20(27):2427-2441.
APA	Lu, Lina.,Kang, Shuhe.,Sun, Chao.,Sun, Chufeng.,Guo, Zhong.,...&Liu, Bin.(2020).Multifunctional Nanoparticles in Precise Cancer Treatment: Considerations in Design and Functionalization of Nanocarriers.CURRENT TOPICS IN MEDICINAL CHEMISTRY,20(27),2427-2441.
MLA	Lu, Lina,et al."Multifunctional Nanoparticles in Precise Cancer Treatment: Considerations in Design and Functionalization of Nanocarriers".CURRENT TOPICS IN MEDICINAL CHEMISTRY 20.27(2020):2427-2441.