Individual and successive detection of H2S and HClO in living cells and zebrafish by a dual-channel fluorescent probe with longer emission wavelength

doi:10.1016/j.aca.2021.338362

	Individual and successive detection of H2S and HClO in living cells and zebrafish by a dual-channel fluorescent probe with longer emission wavelength
	Cheng, Wei 3; Xue, Xuqi 3; Gan, Lu 4; Jin, Peng 3; Zhang, Baoxin 3; Guo, Menghuan 4; Si, Jing 4; Du, Hongying 1; Chen, Hongli 3; Fang, Jianguo 3
刊名	ANALYTICA CHIMICA ACTA
	2021-04-29
卷号	1156 页码:9
关键词	Dual-channel fluorescent probe HClO and H2S Turn-on Individual and successive detection Bioimaging
ISSN号	0003-2670
DOI	10.1016/j.aca.2021.338362
通讯作者	Du, Hongying(hydu@mail.hzau.edu.cn) ; Chen, Hongli(hlchen@lzu.edu.cn)
英文摘要	Reactive oxygen species (ROS) and reactive sulfur species (RSS) participate in many physiological activities and help maintaining the redox homeostasis in biological system. The complicated intrinsic connection between specific ROS/RSS needs to be further explored. Herein, a novel fluorescent probe (MB-NAP-N-3) with longer emission wavelength has been rationally designed and synthesized based on the conjugation of the methylene blue moiety and the naphthalimide moiety for the detection of hypochlorous acid (HClO) and hydrogen sulfide (H2S). The dual-signal probe exhibits rapid turn-on fluorescence responses for individual and successive detection of H2S and HClO in green and red channels, respectively. Owning to its advantages such as fast response, good selectivity and high sensitivity, the probe was successfully applied to detect endogenous and exogenous HClO/H2S in living cells. Furthermore, the outstanding luminescence performance makes it suitable for the visualization of the in vivo interaction between the two analytes in zebrafish. (C) 2021 Elsevier B.V. All rights reserved.
资助项目	National Natural Science Foundation of China[21874060] ; Ministry of Science and Technology, National Key RD Project[2018YFE0205100]
WOS研究方向	Chemistry
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000632679500001
资助机构	National Natural Science Foundation of China ; Ministry of Science and Technology, National Key RD Project
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/137727]
专题	中国科学院近代物理研究所
通讯作者	Du, Hongying; Chen, Hongli
作者单位	1.Huazhong Agr Univ, Coll Food Sci & Technol, Key Lab Environm Correlat Dietol, Minist Educ, Wuhan 430071, Peoples R China 2.Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China 3.Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China 4.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Cheng, Wei,Xue, Xuqi,Gan, Lu,et al. Individual and successive detection of H2S and HClO in living cells and zebrafish by a dual-channel fluorescent probe with longer emission wavelength[J]. ANALYTICA CHIMICA ACTA,2021,1156:9.
APA	Cheng, Wei.,Xue, Xuqi.,Gan, Lu.,Jin, Peng.,Zhang, Baoxin.,...&Fang, Jianguo.(2021).Individual and successive detection of H2S and HClO in living cells and zebrafish by a dual-channel fluorescent probe with longer emission wavelength.ANALYTICA CHIMICA ACTA,1156,9.
MLA	Cheng, Wei,et al."Individual and successive detection of H2S and HClO in living cells and zebrafish by a dual-channel fluorescent probe with longer emission wavelength".ANALYTICA CHIMICA ACTA 1156(2021):9.