Red Fluorescent Emissive Gd-Phenolic Nanoparticles for In Vivo Fluorescence and Magnetic Resonance Bimodal Imaging

doi:10.1166/jbn.2021.3136

	Red Fluorescent Emissive Gd-Phenolic Nanoparticles for In Vivo Fluorescence and Magnetic Resonance Bimodal Imaging
	Xu, Weibing 2; Zhang, Jia 2; Zhao, Minzhi 2; Yang, Zhijie 1; Wu, Qingfeng 3; Nian, Fang 2
刊名	JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
	2021-08-01
卷号	17 期号:8 页码:1635-1646
关键词	Gadolinium Coordination Polymer Dual-Mode Imaging Fluorescence Magnetic Resonance
ISSN号	1550-7033
DOI	10.1166/jbn.2021.3136
通讯作者	Xu, Weibing(xuwb@gsau.edu.cn) ; Nian, Fang(nianf@gsau.edu.cn)
英文摘要	Due to the combination of the high resolution of fluorescence imaging and the no limitation in penetration depth of magnetic resonance imaging, dual-mode imaging of magnetic resonance and fluorescence (MR/FI) have attracted extensive research in recent years. Herein, a novel MR/FI bimodal imaging probe is facile fabricated by attaching the rhodamine fluorophore covalently to the surface of the Gd-phenolic coordination polymer nanoparticles. The contents of Gd3+ and RB of the as prepared probe are calculated to be 8.2% and 12.5%. The quantum yield of the probe is about 8.84% as well as red fluorescent emissive. The longitudinal r1 value is 6.94 mM-1 s-1 and the ratio r2/r1 is very low and about 1.22. Subsequently, the and MR imaging and fluorescence both in vitro and in vivo are performed. The metabolic pathways in vivo are inferred by studying the bio-distribution of the probe in major organs. The as-prepared probe exhibits excellent P: 49249253 194 On: Wed 22 Sep 202 06:11:59 imaging performance and biocompatibility, whicis conduive to its further application.
资助项目	Natural Science Foundation of Gansu Province[20JR10RA511] ; Natural Science Foundation of Gansu Province[2019B-084] ; Scientific Research start-up funds for openly-recruited doctors of Gansu Agricultural University[2017RCZX-42]
WOS关键词	FACILE HYDROTHERMAL SYNTHESIS ; CARBON QUANTUM DOTS ; ELECTRODE MATERIALS ; CONTRAST AGENT ; PROBE ; CHEMOSENSOR ; COMPOSITES ; RHODAMINE ; FE3+
WOS研究方向	Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER SCIENTIFIC PUBLISHERS
WOS记录号	WOS:000701689400001
资助机构	Natural Science Foundation of Gansu Province ; Scientific Research start-up funds for openly-recruited doctors of Gansu Agricultural University
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/136291]
专题	中国科学院近代物理研究所
通讯作者	Xu, Weibing; Nian, Fang
作者单位	1.Gansu Agr Univ, Coll Life Sci, Lanzhou 730000, Peoples R China 2.Gansu Agr Univ, Coll Sci, Lanzhou 730000, Peoples R China 3.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Xu, Weibing,Zhang, Jia,Zhao, Minzhi,et al. Red Fluorescent Emissive Gd-Phenolic Nanoparticles for In Vivo Fluorescence and Magnetic Resonance Bimodal Imaging[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2021,17(8):1635-1646.
APA	Xu, Weibing,Zhang, Jia,Zhao, Minzhi,Yang, Zhijie,Wu, Qingfeng,&Nian, Fang.(2021).Red Fluorescent Emissive Gd-Phenolic Nanoparticles for In Vivo Fluorescence and Magnetic Resonance Bimodal Imaging.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,17(8),1635-1646.
MLA	Xu, Weibing,et al."Red Fluorescent Emissive Gd-Phenolic Nanoparticles for In Vivo Fluorescence and Magnetic Resonance Bimodal Imaging".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 17.8(2021):1635-1646.