Revealing the effects of multi-scale molecules on alpha-linolenic acid-loaded W-1/O/W-2 microemulsion: A combined study from physical properties, antioxidant capacity and in vitro release kinetics

doi:10.1016/j.molliq.2020.112675

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	Revealing the effects of multi-scale molecules on alpha-linolenic acid-loaded W-1/O/W-2 microemulsion: A combined study from physical properties, antioxidant capacity and in vitro release kinetics
	Li, Qing ; Liu, Xiaoxue ; Byambasuren, Khorolgarav ; Wang, Xueping ; Qiu, Shuang ; Gao, Yujie ; Dang, Leping ; Liu, Zhengan 1; Shu, Qingyan 1; Wang, Zhanzhong
刊名	JOURNAL OF MOLECULAR LIQUIDS
	2020
卷号	303
关键词	W1/O/W-2 microemulsion Multi-scale molecules Properties Antioxidant capacity Release kinetics
ISSN号	0167-7322
DOI	10.1016/j.molliq.2020.112675
文献子类	Article
英文摘要	The effects of multi-scale molecules on physical properties, antioxidant capacity and in vitro release kinetics in the alpha-linolenic acid-loaded water-in-oil-in-water (W-1/O/W-2) microemulsion were revealed in this work. The glucose and carboxymethyl cellulose sodium (CMC) solutions were selected as the internal aqueous phase (W-1) of the microemulsion, respectively, while the multi-scale molecules, such as sodium chloride (NaCl), glycine (Gly), glucose (Glu), CMC, bovine serum albumin (BSA) and sodium caseinate (SC), were added in the external aqueous phase (W-2) to balance the osmotic pressure and meanwhile their effects on the fluorescence property, antioxidant capacity and release kinetics were probed. Among these, the CMCw1-NaClw2 and Glu(w1)-CMCw2 microemulsion within the appropriate concentration range could dramatically increase the storage stability and antioxidant capacity by inhibiting the aggregation of droplets or Ostwald ripening, while the addition of Gly and SC had the negative effect on the stability of microemulsion. Finally, the release kinetic dates were fitted and the Koismeyer-Peppas equation was considered as the most suitable to explain the ALA release kinetics that were controlled by diffusion and erosion in the simulated gastric fluid (SGF, pH = 2.0) and simulated intestinal fluid (SIF, pH = 6.8). The application of release kinetic models in nutrient nano-delivery systems could facilitate the investigation on the release mechanism of nutritional components. (C) 2020 Published by Elsevier B.V.
学科主题	Chemistry, Physical ; Physics, Atomic, Molecular & Chemical
电子版国际标准刊号	1873-3166
出版地	AMSTERDAM
WOS关键词	MULTIPLE W/O/W EMULSIONS ; STABILITY ; DELIVERY ; EMULSIFICATION ; ADDITIVES ; PROFILES ; BEHAVIOR ; SYSTEMS
WOS研究方向	Chemistry ; Physics
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000533612700078
资助机构	Strategic Priority Research Program of the Chinese Academy of SciencesChinese Academy of Sciences [XDA23080601] ; Tianjin Municipal Natural Science FoundationNatural Science Foundation of Tianjin [17JCYBJC20400]
内容类型	期刊论文
源URL	[http://ir.ibcas.ac.cn/handle/2S10CLM1/21760]
专题	中科院北方资源植物重点实验室
作者单位	1.Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China 2.Chinese Acad Sci, Inst Bot, Key Lab Plant Resources, Beijing Bot Garden, Beijing 100093, Peoples R China
推荐引用方式 GB/T 7714	Li, Qing,Liu, Xiaoxue,Byambasuren, Khorolgarav,et al. Revealing the effects of multi-scale molecules on alpha-linolenic acid-loaded W-1/O/W-2 microemulsion: A combined study from physical properties, antioxidant capacity and in vitro release kinetics[J]. JOURNAL OF MOLECULAR LIQUIDS,2020,303.
APA	Li, Qing.,Liu, Xiaoxue.,Byambasuren, Khorolgarav.,Wang, Xueping.,Qiu, Shuang.,...&Wang, Zhanzhong.(2020).Revealing the effects of multi-scale molecules on alpha-linolenic acid-loaded W-1/O/W-2 microemulsion: A combined study from physical properties, antioxidant capacity and in vitro release kinetics.JOURNAL OF MOLECULAR LIQUIDS,303.
MLA	Li, Qing,et al."Revealing the effects of multi-scale molecules on alpha-linolenic acid-loaded W-1/O/W-2 microemulsion: A combined study from physical properties, antioxidant capacity and in vitro release kinetics".JOURNAL OF MOLECULAR LIQUIDS 303(2020).