In Vitro Evaluation of a Fluorescent Microemulsion as an Oral Delivery Carrier and its Potential Application in Tracking Bioactive Compounds Label-Free

doi:10.1021/acs.jafc.0c00341

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	In Vitro Evaluation of a Fluorescent Microemulsion as an Oral Delivery Carrier and its Potential Application in Tracking Bioactive Compounds Label-Free
	Wang, Zhanzhong ; Liu, Xiaoxue ; Li, Qing ; Qiu, Shuang ; Wang, Xueping ; Byambasuren, Khorolgarav ; Liu, Zhengan 2; Dang, Leping ; Shu, Qingyan 2
刊名	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
	2020
卷号	68 期号:33 页码:8996-9003
关键词	fluorescent microemulsion antidigestion remarkable fluorescence intensity release property label-free delivery carrier
ISSN号	0021-8561
DOI	10.1021/acs.jafc.0c00341
文献子类	Article
英文摘要	In this work, a microemulsion emitting fluorescence was fabricated as a potential oral delivery system for bioactive compounds. In simulated oral administration, the microemulsion was characterized for its microstructure by 'hydrogen-nuclear magnetic resonance (H-1-NMR). Results showed that microemulsions not only have good resistance to oral and gastric phases, but also lay a solid foundation for the release of bioactive compounds in the intestine. Fluorescence stability tests showed that microemulsions exhibit a remarkable fluorescence intensity in the digestive environment, indicating feasibility as a label-free delivery carrier. Moreover, in vitro release tests of bioactive compounds confirmed that an alpha-linolenic acid (ALA)-loaded microemulsion mainly released in the intestine, thereby achieving the aim of controlling the release of bioactive compounds. These results suggest that the synthesized fluorescent microemulsion, combining the favorable features of nontoxicity, antidigestive stability, remarkable fluorescence intensity, and controllable release, can be regarded as a promising label-free delivery carrier for oral administration.
学科主题	Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
电子版国际标准刊号	1520-5118
出版地	WASHINGTON
WOS关键词	LIPID DIGESTION ; EMULSIONS ; BIOACCESSIBILITY ; BIOAVAILABILITY ; NANOPARTICLES ; NANOEMULSIONS ; ENCAPSULATION ; BIOPOLYMER ; STABILITY ; CAPACITY
WOS研究方向	Agriculture ; Chemistry ; Food Science & Technology
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000563071500025
资助机构	Strategic Priority Research Program of the Chinese Academy of SciencesChinese Academy of Sciences [XDA23080601] ; Key Laboratory of Plant Resources, Institute of Botany, the Chinese Academy of Sciences [KLPR2019-02, 2019GKF-0238] ; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21978206]
内容类型	期刊论文
源URL	[http://ir.ibcas.ac.cn/handle/2S10CLM1/21613]
专题	中科院北方资源植物重点实验室
作者单位	1.Chinese Acad Sci, Inst Bot, Key Lab Plant Resources, Beijing Bot Garden, Beijing 100093, Peoples R China 2.Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China
推荐引用方式 GB/T 7714	Wang, Zhanzhong,Liu, Xiaoxue,Li, Qing,et al. In Vitro Evaluation of a Fluorescent Microemulsion as an Oral Delivery Carrier and its Potential Application in Tracking Bioactive Compounds Label-Free[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2020,68(33):8996-9003.
APA	Wang, Zhanzhong.,Liu, Xiaoxue.,Li, Qing.,Qiu, Shuang.,Wang, Xueping.,...&Shu, Qingyan.(2020).In Vitro Evaluation of a Fluorescent Microemulsion as an Oral Delivery Carrier and its Potential Application in Tracking Bioactive Compounds Label-Free.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,68(33),8996-9003.
MLA	Wang, Zhanzhong,et al."In Vitro Evaluation of a Fluorescent Microemulsion as an Oral Delivery Carrier and its Potential Application in Tracking Bioactive Compounds Label-Free".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 68.33(2020):8996-9003.