Oxygen Self-Supply Engineering-Ferritin for the Relief of Hypoxia in Tumors and the Enhancement of Photodynamic Therapy Efficacy

doi:10.1002/smll.202200116

	Oxygen Self-Supply Engineering-Ferritin for the Relief of Hypoxia in Tumors and the Enhancement of Photodynamic Therapy Efficacy
	Zhu, Yang 1; Jin, Duo 1; Liu, Manman 1; Dai, Yi 1; Li, Li 1; Zheng, Xinwei 2; Wang, Lulu 2; Shen, Aizong 1; Yu, Jianing 1; Wu, Sisi 1
刊名	SMALL
	2022-02-25
关键词	ferritin manganese dioxide photodynamic therapy tumor therapies
ISSN号	1613-6810
DOI	10.1002/smll.202200116
通讯作者	Shen, Aizong(shenaizong@ustc.edu.cn) ; Cheng, Junjie(jjcheng2017@ustc.edu.cn) ; Liu, Yangzhong(liuyz@ustc.edu.cn)
英文摘要	Hypoxia is a hallmark of the tumor microenvironment (TME) that promotes tumor development and metastasis. Photodynamic therapy (PDT) is a promising strategy in the treatment of tumors, but it is limited by the lack of oxygen in TME. In this work, an O-2 self-supply PDT system is constructed by co-encapsulation of chlorin e6 (Ce6) and a MnO2 core in an engineered ferritin (Ftn), generating a nanozyme promoted PDT nanoformula (Ce6/Ftn@MnO2) for tumor therapy. Ce6/Ftn@MnO2 exhibits a uniform small size (15.5 nm) and high stability due to the inherent structure of Ftn. The fluorescence imaging and immunofluorescence analysis demonstrate the pronounced accumulation of Ce6/Ftn@MnO2 in the tumors of mice, and the treatment significantly decreases the expression of hypoxia-inducible factor (HIF)-1 alpha. The Ce6/Ftn@MnO2 nanoplatform exerts a more potent anti-tumor efficacy with negligible damage to normal tissues compared to the treatment with free Ce6. Moreover, the weak acidity and the presence of H2O2 in TME significantly enhances the r(1) relativity of Ce6/Ftn@MnO2, resulting in a prominent enhancement of MRI imaging in the tumor. This bio-mimic Ftn strategy not only improves the in vivo distribution and retention of Ce6, but also enhances the effectiveness and precision of PDT by TME modulation.
资助项目	National Key R&D Program of China[2020YFA0710700] ; National Key R&D Program of China[2017YFA0505400] ; National Natural Science Foundation of China[52021002] ; National Natural Science Foundation of China[21877103] ; National Natural Science Foundation of China[22177109] ; National Natural Science Foundation of China[32101121] ; Users with Excellence Program of Hefei Science Center CAS[2020HSC-UE016] ; Fundamental Research Funds for the Central Universities[WK3450000007]
WOS关键词	AGGREGATION-INDUCED EMISSION ; ALBUMIN-MNO2 NANOPARTICLES ; MNO2 NANOPARTICLES ; CANCER ; NANOCAGES ; MICROENVIRONMENT ; NANOCARRIERS ; CHEMOTHERAPY ; APOPTOSIS ; PLATFORM
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000760890800001
资助机构	National Key R&D Program of China ; National Natural Science Foundation of China ; Users with Excellence Program of Hefei Science Center CAS ; Fundamental Research Funds for the Central Universities
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/127951]
专题	中国科学院合肥物质科学研究院
通讯作者	Shen, Aizong; Cheng, Junjie; Liu, Yangzhong
作者单位	1.Univ Sci & Technol China, Dept Chem, Div Life Sci & Med, Affiliated Hosp 1,Dept Pharm, Hefei 230001, Peoples R China 2.Chinese Acad Sci, High Magnet Field Lab, Hefei 230031, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Yang,Jin, Duo,Liu, Manman,et al. Oxygen Self-Supply Engineering-Ferritin for the Relief of Hypoxia in Tumors and the Enhancement of Photodynamic Therapy Efficacy[J]. SMALL,2022.
APA	Zhu, Yang.,Jin, Duo.,Liu, Manman.,Dai, Yi.,Li, Li.,...&Liu, Yangzhong.(2022).Oxygen Self-Supply Engineering-Ferritin for the Relief of Hypoxia in Tumors and the Enhancement of Photodynamic Therapy Efficacy.SMALL.
MLA	Zhu, Yang,et al."Oxygen Self-Supply Engineering-Ferritin for the Relief of Hypoxia in Tumors and the Enhancement of Photodynamic Therapy Efficacy".SMALL (2022).