Spatiotemporal Control of Molecular Cascade Reactions by a Reconfigurable DNA Origami Domino Array

doi:10.1002/anie.202116324

	Spatiotemporal Control of Molecular Cascade Reactions by a Reconfigurable DNA Origami Domino Array
	Fan, Sisi 4; Ji, Bin 4; Liu, Yan 4; Zou, Kexuan 4; Tian, Zhijin 1,3; Dai, Bin 4; Cui, Daxiang 4; Zhang, Pengfei 1; Ke, Yonggang 2,5; Song, Jie 1,4
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2022-01-11
关键词	cascade reactions dynamic regulation reconfigurable DNA origami spatial control
ISSN号	1433-7851
DOI	10.1002/anie.202116324
通讯作者	Song, Jie(sjie@sjtu.edu.cn)
英文摘要	Inspired by efficient biomolecular reactions in the cell, versatile DNA nanostructures have been explored for manipulating the spatial position and regulating reactions at the molecular level. Spatially controlled arrangement of molecules on the artificial scaffolds generally leads to enhanced reaction activities. Especially, the rich toolset of dynamic DNA nanostructures provides a potential route towards more sophisticated and vigorous regulation of molecular reactions. Herein, a reconfigurable DNA origami domino array (DODA) as a dynamic scaffold was adopted in this work for temporal-controlled and switchable molecular cascade reactions. Dynamic regulation of the assembly of G-quadruplex, hybridization of parallel-stranded duplex and assembly of binary DNAzyme were demonstrated. Molecular cascade reactions on the triggered reconfiguration of DODAs were realized, resulting in more complex, dynamic, and switchable control over the reactions.
资助项目	National Natural Science Foundation of China[81822024] ; National Natural Science Foundation of China[22161132008] ; Natural Science Foundation of Shanghai, China[19520714100] ; Natural Science Foundation of Shanghai, China[19ZR1475800] ; Project of Shanghai Jiao Tong University[2019QYA03] ; Project of Shanghai Jiao Tong University[YG2017ZD07] ; Starry Night Science Fund of Zhejiang University Shanghai Institute for Advanced Study[SN-ZJU-SIAS-006] ; Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences ; Zhiyuan Innovative Research Center, SJTU
WOS关键词	NANOROBOT
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000741469700001
资助机构	National Natural Science Foundation of China ; Natural Science Foundation of Shanghai, China ; Project of Shanghai Jiao Tong University ; Starry Night Science Fund of Zhejiang University Shanghai Institute for Advanced Study ; Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences ; Zhiyuan Innovative Research Center, SJTU
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/127097]
专题	中国科学院合肥物质科学研究院
通讯作者	Song, Jie
作者单位	1.Chinese Acad Sci, Inst Canc & Basic Med IBMC, Canc Hosp, Univ Chinese Acad Sci, Hangzhou 310022, Zhejiang, Peoples R China 2.Georgia Inst Technol, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30322 USA 3.Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China 4.Shanghai Jiao Tong Univ, Inst Nano Biomed & Engn, Dept Instrument Sci & Engn, Sch Elect Informat & Elect Engn, Shanghai 200240, Peoples R China 5.Emory Univ, Atlanta, GA 30322 USA
推荐引用方式 GB/T 7714	Fan, Sisi,Ji, Bin,Liu, Yan,et al. Spatiotemporal Control of Molecular Cascade Reactions by a Reconfigurable DNA Origami Domino Array[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2022.
APA	Fan, Sisi.,Ji, Bin.,Liu, Yan.,Zou, Kexuan.,Tian, Zhijin.,...&Song, Jie.(2022).Spatiotemporal Control of Molecular Cascade Reactions by a Reconfigurable DNA Origami Domino Array.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION.
MLA	Fan, Sisi,et al."Spatiotemporal Control of Molecular Cascade Reactions by a Reconfigurable DNA Origami Domino Array".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022).