Regulating the synthesis rate and yield of bio-assembled FeS nanoparticles for efficient cancer therapy

doi:10.1039/d1nr03591f

	Regulating the synthesis rate and yield of bio-assembled FeS nanoparticles for efficient cancer therapy
	Dang, Zheng 2; Guan, Yong 2; Wu, Zhao 2; Tao, Xia-Yu 2; Xiong, Ying 2; Bai, Hao-Bo 2; Shao, Chang-Sheng 1,3; Liu, Gang 2; Huang, Qing 1,3; Tian, Li-Jiao 2
刊名	NANOSCALE
	2021-10-11
ISSN号	2040-3364
DOI	10.1039/d1nr03591f
通讯作者	Tian, Li-Jiao(ljtian@ustc.edu.cn) ; Tian, Yang-Chao(ychtian@ustc.edu.cn)
英文摘要	Biosynthesis has gained growing interest due to its energy efficiency and environmentally benign nature. Recently, biogenic iron sulfide nanoparticles (FeS NPs) have exhibited excellent performance in environmental remediation and energy recovery applications. However, their biosynthesis regulation strategy and application prospects in the biomedical field remain to be explored. Herein, biogenic FeS NPs are controllably synthesized by Shewanella oneidensis MR-1 and applied for cancer therapy. Tuning the synthesis rate and yield of biogenic FeS NPs is realized by altering the initial iron precursor dosage. Notably, increasing the precursor concentration decreases and delays FeS NP biosynthesis. The biogenic FeS NPs (30 nm) are homogeneously anchored on the cell surface of S. oneidensis MR-1. Moreover, the good hydrophilic nature and outstanding Fenton properties of the as-prepared FeS NPs endow them with good cancer therapy performance. The intracellular location of the FeS NPs taken up is visualized with a soft X-ray microscope (SXM). Highly efficient cancer cell killing can be achieved at extremely low concentrations (<12 mu g mL(-1)), lower than those in reported works. Such good performance is attributed to the Fe2+ release, elevated ROS, reduced glutathione (GSH) consumption, and lipid hydroperoxide (LPO) generation. The resulting FeS NPs show excellent in vivo therapeutic performance. This work provides a facile, eco-friendly, and scalable approach to produce nanomedicine, demonstrating the potential of biogenic nanoparticles for use in cancer therapy.
资助项目	National Key Research and Development Program of China[2017YFA0402904] ; National Natural Science Foundation of China[21907087] ; National Natural Science Foundation of China[11775224] ; National Natural Science Foundation of China[U2032148] ; Natural Science Foundation of Anhui Province[1908085MB31] ; Fundamental Research Funds for the Central Universities[WK2060000003] ; Fundamental Research Funds for the Central Universities[WK2310000100] ; Youth Innovation Promotion Association, CAS[2020457]
WOS关键词	QUANTUM DOTS ; SHEWANELLA ; BIOSYNTHESIS
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000711597100001
资助机构	National Key Research and Development Program of China ; National Natural Science Foundation of China ; Natural Science Foundation of Anhui Province ; Fundamental Research Funds for the Central Universities ; Youth Innovation Promotion Association, CAS
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/125780]
专题	中国科学院合肥物质科学研究院
通讯作者	Tian, Li-Jiao; Tian, Yang-Chao
作者单位	1.Chinese Acad Sci, Hefei Inst Phys Sci, CAS Key Lab High Magnet Field & Ion Beam Phys Bio, Hefei 230031, Peoples R China 2.Univ Sci & Technol China, Natl Synchrotron Radiat Lab, Hefei 230026, Peoples R China 3.Univ Sci & Technol China, Sci Isl Branch, Grad Sch, Hefei 230026, Peoples R China
推荐引用方式 GB/T 7714	Dang, Zheng,Guan, Yong,Wu, Zhao,et al. Regulating the synthesis rate and yield of bio-assembled FeS nanoparticles for efficient cancer therapy[J]. NANOSCALE,2021.
APA	Dang, Zheng.,Guan, Yong.,Wu, Zhao.,Tao, Xia-Yu.,Xiong, Ying.,...&Tian, Yang-Chao.(2021).Regulating the synthesis rate and yield of bio-assembled FeS nanoparticles for efficient cancer therapy.NANOSCALE.
MLA	Dang, Zheng,et al."Regulating the synthesis rate and yield of bio-assembled FeS nanoparticles for efficient cancer therapy".NANOSCALE (2021).