Two Clusters of GABAergic Ellipsoid Body Neurons Modulate Olfactory Labile Memory in Drosophila

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	Two Clusters of GABAergic Ellipsoid Body Neurons Modulate Olfactory Labile Memory in Drosophila
	Guo, AK
刊名	JOURNAL OF NEUROSCIENCE
	2013
卷号	33 期号:12 页码:5175-5181
关键词	LONG-TERM-MEMORY ANESTHESIA-SENSITIVE MEMORY CENTRAL COMPLEX MUSHROOM BODY DOPAMINERGIC-NEURONS CONSOLIDATED MEMORY MELANOGASTER ORIENTATION RETENTION RECEPTORS
ISSN号	0270-6474
通讯作者	Guo, AK (reprint author), Inst Biophys, 15 Datun Rd, Beijing 100101, Peoples R China.,liyan@ibp.ac.cn
英文摘要	In Drosophila, aversive olfactory memory is believed to be stored in a prominent brain structure, the mushroom body (MB), and two pairs of MB intrinsic neurons, the dorsal paired medial (DPM) and the anterior paired lateral (APL) neurons, are found to regulate the consolidation of middle-term memory (MTM). Here we report that another prominent brain structure, the ellipsoid body (EB), is also involved in the modulation of olfactory MTM. Activating EB R2/R4m neurons does not affect the learning index, but specifically eliminates anesthesia-sensitive memory (ASM), the labile component of olfactory MTM. We further demonstrate that approximately two-thirds of these EB neurons are GABAergic and are responsible for the suppression of ASM. Using GRASP (GFP reconstitution across synaptic partners), we reveal potential synaptic connections between the EB and MB in regions covering both the presynaptic and postsynaptic sites of EB neurons, suggesting the presence of bidirectional connections between these two important brain structures. These findings suggest the existence of direct connections between the MB and EB, and provide new insights into the neural circuit basis for olfactory labile memory in Drosophila.
学科主题	Neurosciences & Neurology
收录类别	SCI
资助信息	973 Program [2011CBA00400]; National Science Foundation of China [30921064, 90820008, 31130027, 31070956, 91132709]; CAS [KSCX2-YW-R-156]; Chinese Academy of Sciences [XDB02040100]
语种	英语
公开日期	2013-10-14
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2560]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Guo, AK. Two Clusters of GABAergic Ellipsoid Body Neurons Modulate Olfactory Labile Memory in Drosophila[J]. JOURNAL OF NEUROSCIENCE,2013,33(12):5175-5181.
APA	Guo, AK.(2013).Two Clusters of GABAergic Ellipsoid Body Neurons Modulate Olfactory Labile Memory in Drosophila.JOURNAL OF NEUROSCIENCE,33(12),5175-5181.
MLA	Guo, AK."Two Clusters of GABAergic Ellipsoid Body Neurons Modulate Olfactory Labile Memory in Drosophila".JOURNAL OF NEUROSCIENCE 33.12(2013):5175-5181.