Comparative genomics provides insights into the aquatic adaptations of mammals

doi:10.1073/pnas.2106080118

CORC > 深海科学与工程研究所 > 中国科学院深海科学与工程研究所 > 深海科学研究部 > 深海生物学研究室 > 海洋哺乳动物与海洋生物声学研究组

	Comparative genomics provides insights into the aquatic adaptations of mammals
	Yuan, Yuan 4,5; Zhang, Yaolei 13,14,16; Zhang, Peijun 5; Liu, Chang 4; Wang, Jiahao 3,16; Gao, Haiyu 5; Hoelzel, A. Rus 1; Seim, Inge 15,17; Lv, Meiqi 16; Lin, Mingli 5
刊名	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
	2021-09-14
卷号	118 期号:37 页码:9
关键词	marine mammals comparative genomics aquatic adaptation
ISSN号	0027-8424
DOI	10.1073/pnas.2106080118
英文摘要	The ancestors of marine mammals once roamed the land and independently committed to an aquatic lifestyle. These macroevolutionary transitions have intrigued scientists for centuries. Here, we generated high-quality genome assemblies of 17 marine mammals (11 cetaceans and six pinnipeds), including eight assemblies at the chromosome level. Incorporating previously published data, we reconstructed the marine mammal phylogeny and population histories and identified numerous idiosyncratic and convergent genomic variations that possibly contributed to the transition from land to water in marine mammal lineages. Genes associated with the formation of blubber (NFIA), vascular development (SEMA3E), and heat production by brown adipose tissue (UCP1) had unique changes that may contribute to marine mammal thermoregulation. We also observed many lineage-specific changes in the marine mammals, including genes associated with deep diving and navigation. Our study advances understanding of the timing, pattern, and molecular changes associated with the evolution of mammalian lineages adapting to aquatic life.
资助项目	National Natural Science Foundation of China[41422604] ; National Natural Science Foundation of China[41306169] ; One Road Science and Tech-nology Cooperation Special Program of the International Partnership Program of the Chinese Academy of Sciences[183446KYSB20200016] ; Key Deployment Project of Center for Ocean Mega-Science of the Chinese Academy of Sciences[COMS2020Q15] ; Ocean Park Conservation Foundation of Hong Kong[MM02-1516] ; Research Funds for Interdisci-plinary Subject, Northwestern Polytechnical University[19SH030408] ; 1,000 Talent Project of Shaanxi Province ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2020363] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA19060403] ; Danish National Research Foundation[DNRF96] ; Fundacao para a Ciencia e a Tecnologia, under the Scientific Employment Stimulus Initiative[CEECIND/01799/2017]
WOS关键词	INNER-EAR PROTEIN ; SPERM-WHALES ; BROWN FAT ; EVOLUTION ; TRANSITIONS ; RESOLUTION ; ADMIXTURE ; POLAR ; GAMMA ; XYLT1
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	NATL ACAD SCIENCES
WOS记录号	WOS:000697000500003
资助机构	National Natural Science Foundation of China ; One Road Science and Tech-nology Cooperation Special Program of the International Partnership Program of the Chinese Academy of Sciences ; Key Deployment Project of Center for Ocean Mega-Science of the Chinese Academy of Sciences ; Ocean Park Conservation Foundation of Hong Kong ; Research Funds for Interdisci-plinary Subject, Northwestern Polytechnical University ; 1,000 Talent Project of Shaanxi Province ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Danish National Research Foundation ; Fundacao para a Ciencia e a Tecnologia, under the Scientific Employment Stimulus Initiative
内容类型	期刊论文
源URL	[http://ir.idsse.ac.cn/handle/183446/8892]
专题	深海科学研究部_深海生物学研究室_海洋哺乳动物与海洋生物声学研究组
通讯作者	Fan, Guangyi; Wang, Kun; Li, Songhai
作者单位	1.Univ Durham, Dept Biosci, Durham DH1 3LE, England 2.Univ Copenhagen, Globe Inst, Ctr Macroecol Evolut & Climate, DK-1165 Copenhagen, Denmark 3.BGI Shenzhen, State Key Lab Agr Genom, Shenzhen 518083, Peoples R China 4.Northwestern Polytech Univ, Sch Ecol & Environm, Xian 710072, Peoples R China 5.Chinese Acad Sci, Inst Deep Sea Sci & Engn, Marine Mammal & Marine Bioacoust Lab, Sanya 572000, Peoples R China 6.Chinese Acad Sci, Key Lab Aquat Biodivers & Conservat, Inst Hydrobiol, Wuhan 430072, Peoples R China 7.Minist Nat Resources, Lab Marine Biol & Ecol, Inst Oceanog 3, Xiamen 361005, Peoples R China 8.Univ Iceland, Res Ctr Husavik, IS-640 Husavik, Iceland 9.Univ Porto, Interdisciplinary Ctr Marine & Environm Res, P-4450208 Matosinhos, Portugal 10.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China
推荐引用方式 GB/T 7714	Yuan, Yuan,Zhang, Yaolei,Zhang, Peijun,et al. Comparative genomics provides insights into the aquatic adaptations of mammals[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2021,118(37):9.
APA	Yuan, Yuan.,Zhang, Yaolei.,Zhang, Peijun.,Liu, Chang.,Wang, Jiahao.,...&Li, Songhai.(2021).Comparative genomics provides insights into the aquatic adaptations of mammals.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,118(37),9.
MLA	Yuan, Yuan,et al."Comparative genomics provides insights into the aquatic adaptations of mammals".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 118.37(2021):9.