Iridoid Constituents of Viburnum brachybotryum

doi:10.1021/acs.jnatprod.1c00042

	Iridoid Constituents of Viburnum brachybotryum
	Rao, Li 3; Li, Yao 1; He, Qian 3; Liu, Yu 3; Su, Yu 3; You, Yun-Xia 3; Fan, Yue 3; Lin, Bin 4; Zhang, Yi-Nan 1; Zhang, Chuan-Rui 2,3
刊名	JOURNAL OF NATURAL PRODUCTS
	2021-07-23
卷号	84 期号:7 页码:1915-1923
ISSN号	0163-3864
DOI	10.1021/acs.jnatprod.1c00042
通讯作者	Zhang, Chuan-Rui(crzhang@cqu.edu.cn)
英文摘要	Eleven new iridoids, brachybones A-K (1-11), were isolated from the twigs of Viburnum brachybotryum. Their structures including absolute configurations were determined by spectroscopic data analysis and from the electronic circular dichroism (ECD) spectra. All of the compounds 1-11 possess one or two acetoxysenecioate substituents. Furthermore, compounds 5-7 and 11 feature a Cl atom in the molecule, while compounds 9-11 exhibit a cagelike rigid skeleton through an unusual oxo bridge from C-3 to C-8 or C-10. The isolates were evaluated for cytotoxic activity against the HCT-116, A549, and Hela cell lines, and the results showed compounds 10 and 11 to be active against HCT-116 cells.
资助项目	Chongqing Research and Frontier Technology[cstc2020jcyj-msxmX0537] ; State Key Laboratory of Drug Research[SIMM1903KF-14] ; Fundamental Research Funds for the Central Universities[2020CDJ-LHZZ-006] ; Fundamental Research Funds for the Central Universities[2020CDJQY-A078]
WOS关键词	VIBSANE-TYPE DITERPENOIDS ; LEAVES ; GLYCOSIDES ; ROOTS
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000677582700007
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/298286]
专题	中国科学院上海药物研究所
通讯作者	Zhang, Chuan-Rui
作者单位	1.Nanjing Univ Chinese Med, Sch Pharm, Jiangsu Key Lab Funct Subst Chinese Med, Nanjing 210023, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Chongqing Univ, Sch Pharmaceut Sci, Chongqing Key Lab Nat Prod Synth & Drug Res, Chongqing 401331, Peoples R China 4.Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Peoples R China
推荐引用方式 GB/T 7714	Rao, Li,Li, Yao,He, Qian,et al. Iridoid Constituents of Viburnum brachybotryum[J]. JOURNAL OF NATURAL PRODUCTS,2021,84(7):1915-1923.
APA	Rao, Li.,Li, Yao.,He, Qian.,Liu, Yu.,Su, Yu.,...&Zhang, Chuan-Rui.(2021).Iridoid Constituents of Viburnum brachybotryum.JOURNAL OF NATURAL PRODUCTS,84(7),1915-1923.
MLA	Rao, Li,et al."Iridoid Constituents of Viburnum brachybotryum".JOURNAL OF NATURAL PRODUCTS 84.7(2021):1915-1923.