Sinueretone A, a Diterpenoid with Unprecedented Tricyclo[12.1.0.0(5,9)] pentadecane Carbon Scaffold from the South China Sea Soft Coral Sinularia erecta

doi:10.1021/acs.joc.0c02397

	Sinueretone A, a Diterpenoid with Unprecedented Tricyclo[12.1.0.0(5,9)] pentadecane Carbon Scaffold from the South China Sea Soft Coral Sinularia erecta
	Liu, Jiao 1,2; Li, Heng 1; Wu, Meng-Jun 1,3,4; Tang, Wei 1; Wang, Jian-Rong 1; Gu, Yu-Cheng 5; Wang, Hong 3,4; Li, Xu-Wen 1,2; Guo, Yue-Wei 1,3,4
刊名	JOURNAL OF ORGANIC CHEMISTRY
	2021-08-20
卷号	86 期号:16 页码:10975-10981
ISSN号	0022-3263
DOI	10.1021/acs.joc.0c02397
通讯作者	Li, Xu-Wen(xwli@simm.ac.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要	A novel diterpenoid, sinueretone A (1), featuring an unprecedented tricyclo[12.1.0.0(5,9)]( )pentadecane carbon framework, along with two new (2 and 3) and one known (4) casbane diterpenoids were isolated from the South China Sea soft coral Sinularia erecta. The structures of the new compounds, especially their absolute stereochemistry, were established by extensive spectroscopic analysis, various quantum chemical calculations, and/or X-ray diffraction analyses. A plausible biogenetic relationship of 1 4 was proposed, which gave an insight for future biomimetic synthesis of the novel compounds. In a bioassay, compounds 1 and 2 displayed interesting anti-inflammatory activity by the inhibition of lipopolysaccharide-induced tumor necrosis factor-alpha protein release.
资助项目	National Natural Science Foundation of China (NSFC)[81991521] ; National Natural Science Foundation of China (NSFC)[82022069] ; National Natural Science Foundation of China (NSFC)[42076099] ; NSFC/CNRS joint project[81811530284] ; National Key Research and Development Program of China[2018YFC0310903] ; SKLDR/SIMM Project[SIMM1903ZZ-04] ; Shanghai Rising-Star Program[20QA1411100] ; SA-SIBS Scholarship Program ; Syngenta-SIMM-Ph.D. Studentship Project
WOS关键词	CASBANE DITERPENOIDS ; TERPENOIDS
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000687851300005
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/297727]
专题	中国科学院上海药物研究所
通讯作者	Li, Xu-Wen; Guo, Yue-Wei
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China 4.Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou 310014, Peoples R China 5.Syngenta, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England
推荐引用方式 GB/T 7714	Liu, Jiao,Li, Heng,Wu, Meng-Jun,et al. Sinueretone A, a Diterpenoid with Unprecedented Tricyclo[12.1.0.0(5,9)] pentadecane Carbon Scaffold from the South China Sea Soft Coral Sinularia erecta[J]. JOURNAL OF ORGANIC CHEMISTRY,2021,86(16):10975-10981.
APA	Liu, Jiao.,Li, Heng.,Wu, Meng-Jun.,Tang, Wei.,Wang, Jian-Rong.,...&Guo, Yue-Wei.(2021).Sinueretone A, a Diterpenoid with Unprecedented Tricyclo[12.1.0.0(5,9)] pentadecane Carbon Scaffold from the South China Sea Soft Coral Sinularia erecta.JOURNAL OF ORGANIC CHEMISTRY,86(16),10975-10981.
MLA	Liu, Jiao,et al."Sinueretone A, a Diterpenoid with Unprecedented Tricyclo[12.1.0.0(5,9)] pentadecane Carbon Scaffold from the South China Sea Soft Coral Sinularia erecta".JOURNAL OF ORGANIC CHEMISTRY 86.16(2021):10975-10981.