Stimuli-Sheddable Nanomedicine Overcoming Pathophysiological Barriers for Potentiating Immunotherapy of Cancer

doi:10.1166/jbn.2021.3134

	Stimuli-Sheddable Nanomedicine Overcoming Pathophysiological Barriers for Potentiating Immunotherapy of Cancer
	Wang, Jiaxin 1,2,3; Zhou, Mengxue 2,3; Chen, Fangmin 2,3,4; Liu, Xiao 5; Gao, Jin 2,3; Wang, Weiqi 5; Wang, Hui 1; Yu, Haijun 2,3,4
刊名	JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
	2021-08-01
卷号	17 期号:8 页码:1486-1509
关键词	Cancer Immunotherapy Tumor Microenvironment Stimuli-Responsiveness Sheddable Nanoparticles Pathophysiological Barriers
ISSN号	1550-7033
DOI	10.1166/jbn.2021.3134
通讯作者	Wang, Weiqi(wwq1990@ntu.edu.cn) ; Wang, Hui(cewangh@imu.edu.cn) ; Yu, Haijun(hjyu@simm.ac.cn)
英文摘要	Immunotherapy displays potent potential for clinical cancer management by activating the protective immune response; however, the microenvironment of the immunosuppressive tumor restricts the efficiency of immunotherapies. Along with the complex pathophysiological barrier of the solid tumors, successful immunotherapeutic delivery remains a formidable challenge for conventional nanomedicine. Stimuli-sheddable nano vectors may facilitate the delivery of cargoes to tumors with minimal premature cargo leakage in blood circulation while enhancing the tumor penetration of nanomedicines by deshielding the polyethylene glycol (PEG) coroa upon endogenous activity such as acidity, enzymes and glu-IP: 27.0.0.1 On: Wed, 22 Sep 202 05:54 18 tathione, or external stimuli, such as laser irradiation. Throughout this study, researchers overviewed the recent advances Copyright: American Scentfic Publishers of nanomedicine-based cancer immunotherapy using the stimuli-responsive deshielding nano vectors, which allowed Delivered by Ingenta researchers to integrate multiple therapeutic regimens for inducing immunogenic cell death. This aided in blocking the immune checkpoints, repolarizing the macrophages, and regulating the kynurenine metabolism. Furthermore, researchers discussed the critical issues in the development of stimuli-sheddable nanoimmunodulators, primarily aimed at speeding up their clinical translation. Finally, researchers provided novel perspectives for improving cancer management with the stimuli-sheddable nanomedicine.
资助项目	National Natural Science Foundation of China[51873228] ; National Natural Science Foundation of China[31900990] ; Youth Innovation Promotion Associ-ation of Chinese Academy of Sciences[2014218] ; Open Research Fund of State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of AppliedChemistry, Chinese Academy of Sciences
WOS关键词	TUMOR-ASSOCIATED MACROPHAGES ; INTERSTITIAL FLUID PRESSURE ; IMMUNE CHECKPOINT BLOCKADE ; IMMUNOGENIC CELL-DEATH ; GROWTH-FACTOR VEGF ; M2 MACROPHAGES ; BREAST-CANCER ; PHOTODYNAMIC IMMUNOTHERAPY ; DELIVERY-SYSTEM ; GENE DELIVERY
WOS研究方向	Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER SCIENTIFIC PUBLISHERS
WOS记录号	WOS:000701281700001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/297542]
专题	中国科学院上海药物研究所
通讯作者	Wang, Weiqi; Wang, Hui; Yu, Haijun
作者单位	1.Inner Magnolia Univ, Coll Chem & Chem Engn, Hohhot 010021, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Nantong Univ, Sch Pharm, Nantong 226001, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Wang, Jiaxin,Zhou, Mengxue,Chen, Fangmin,et al. Stimuli-Sheddable Nanomedicine Overcoming Pathophysiological Barriers for Potentiating Immunotherapy of Cancer[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2021,17(8):1486-1509.
APA	Wang, Jiaxin.,Zhou, Mengxue.,Chen, Fangmin.,Liu, Xiao.,Gao, Jin.,...&Yu, Haijun.(2021).Stimuli-Sheddable Nanomedicine Overcoming Pathophysiological Barriers for Potentiating Immunotherapy of Cancer.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,17(8),1486-1509.
MLA	Wang, Jiaxin,et al."Stimuli-Sheddable Nanomedicine Overcoming Pathophysiological Barriers for Potentiating Immunotherapy of Cancer".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 17.8(2021):1486-1509.