Characteristic Malonyl Ginsenosides from the Leaves of Panax notoginseng as Potential Quality Markers for Adulteration Detection

doi:10.1021/acs.jafc.1c00382

	Characteristic Malonyl Ginsenosides from the Leaves of Panax notoginseng as Potential Quality Markers for Adulteration Detection
	Yao, Chang-liang; Wang, Jing; Li, Zhen-wei; Qu, Hua; Pan, Hui-qin; Li, Jia-yuan; Wei, Wen-long; Zhang, Jian-qing; Bi, Qi-rui; Guo, De-an
刊名	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
	2021-04-28
卷号	69 期号:16 页码:4849-4857
关键词	adulteration Panax notoginseng leaves malonyl ginsenosides quality markers
ISSN号	0021-8561
DOI	10.1021/acs.jafc.1c00382
通讯作者	Guo, De-an(daguo@simm.ac.cn)
英文摘要	Due to the high price and limited supply of Panax notoginseng, a large number of samples adulterated with the leaves appear in the market. A group of new malonyl ginsenosides were exclusively detected in the P. notoginseng leaves (PNL). Targeted isolation of the malonyl ginsenosides was guided by UPLC-QDa MS. HRMS, 1D/2D NMR, and chemical methods were used for structural identification. A selected ion monitoring method was developed based on UPLC-QDa MS to detect the adulterations. In addition, the anti-inflammatory activities and the collision-induced dissociation features of the isolated saponins were studied. As a result, eight new 3-OH malonylated dammarane-type triterpene oligoglycosides (notoginsenosides L3-L10) were obtained from PNL. Adulteration with PNL can be easily detected with limit of detection as low as 0.06%. To sum up, the isolated ginsenosides can be used as quality markers for fraud detection, which will promote the quality control of the notoginseng products.
资助项目	National Key R&D Program of China[2019YFC1711000] ; National Key R&D Program of China[2018YFC1707900] ; National Key R&D Program of China[2019YFC1711400] ; National Natural Science Foundation of China[82003938] ; Major Scientific and Technological Special Project of Yunnan Province[2017ZF001-01] ; Project of Science and Technology Program of Yunnan Province[2017IC041]
WOS关键词	METABOLOMICS APPROACH ; FLOWER BUDS ; GINSENG ; SAPONINS ; IDENTIFICATION ; CHROMATOGRAPHY ; DIFFERENTIATION ; DISCOVERY ; EXTRACT ; ROOTS
WOS研究方向	Agriculture ; Chemistry ; Food Science & Technology
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000645559200027
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/297406]
专题	中国科学院上海药物研究所
通讯作者	Guo, De-an
作者单位	Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai Inst Mat Med, Natl Engn Lab TCM Standardizat Technol, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Yao, Chang-liang,Wang, Jing,Li, Zhen-wei,et al. Characteristic Malonyl Ginsenosides from the Leaves of Panax notoginseng as Potential Quality Markers for Adulteration Detection[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2021,69(16):4849-4857.
APA	Yao, Chang-liang.,Wang, Jing.,Li, Zhen-wei.,Qu, Hua.,Pan, Hui-qin.,...&Guo, De-an.(2021).Characteristic Malonyl Ginsenosides from the Leaves of Panax notoginseng as Potential Quality Markers for Adulteration Detection.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,69(16),4849-4857.
MLA	Yao, Chang-liang,et al."Characteristic Malonyl Ginsenosides from the Leaves of Panax notoginseng as Potential Quality Markers for Adulteration Detection".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 69.16(2021):4849-4857.