Preparation of Sulfamates and Sulfamides Using a Selective Sulfamoylation Agent

doi:10.1021/acs.orglett.1c00504

	Preparation of Sulfamates and Sulfamides Using a Selective Sulfamoylation Agent
	Wang, Hai-Ming 1,2; Xiong, Chao-Dong 3,4; Chen, Xiao-Qu 2; Hu, Chun 1; Wang, Dong-Yu 2
刊名	ORGANIC LETTERS
	2021-04-02
卷号	23 期号:7 页码:2595-2599
ISSN号	1523-7060
DOI	10.1021/acs.orglett.1c00504
通讯作者	Hu, Chun(chunhu@syphu.edu.cn) ; Wang, Dong-Yu(wangdongyu@sjtu.edu.cn)
英文摘要	Sulfamates and sulfamides are prevalent in biological molecules, but their universal synthetic methods are limited. We herein report a sulfamoylation agent with high solubility and shelf stability. Various sulfamates and sulfamides can be synthesized directly from alcohols or amines by employing this agent with high selectivity and high yields. This protocol was also successfully used for late-stage sulfamoylation of pharmaceuticals containing a hydroxyl or amino group.
资助项目	National Natural Science Foundation of China[21702216] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program[2018ZX09711002006-003]
WOS关键词	NEDD8-ACTIVATING ENZYME-INHIBITOR ; UBIQUITIN-LIKE PROTEIN ; PEVONEDISTAT TAK-924/MLN4924 ; PHASE-I ; DERIVATIVES ; MLN4924
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000637002800037
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/297390]
专题	中国科学院上海药物研究所
通讯作者	Hu, Chun; Wang, Dong-Yu
作者单位	1.Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med SIMM, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang, Hai-Ming,Xiong, Chao-Dong,Chen, Xiao-Qu,et al. Preparation of Sulfamates and Sulfamides Using a Selective Sulfamoylation Agent[J]. ORGANIC LETTERS,2021,23(7):2595-2599.
APA	Wang, Hai-Ming,Xiong, Chao-Dong,Chen, Xiao-Qu,Hu, Chun,&Wang, Dong-Yu.(2021).Preparation of Sulfamates and Sulfamides Using a Selective Sulfamoylation Agent.ORGANIC LETTERS,23(7),2595-2599.
MLA	Wang, Hai-Ming,et al."Preparation of Sulfamates and Sulfamides Using a Selective Sulfamoylation Agent".ORGANIC LETTERS 23.7(2021):2595-2599.